Searchable abstracts of presentations at key conferences in endocrinology

ea0011p859 | Thyroid | ECE2006

Thyrotropin receptor (TSHR) activation has variable effects on the TNFα axis in preadipocyte and osteoblast-like cell lines

Mandrikoula M , Henry M , Evans BAJ , Ludgate M

In addition to its central role in the control of thyrocyte growth and function, the TSHR is expressed during the differentiation of mesenchymal precursors. To explore further, we have developed an in vitro model in which TSHR activation is achieved by introducing constitutively active (M453T, L629F) TSHR, using retroviral vectors.We aimed to investigate the effect of TSHR activation on body composition, via the production of TNFα and express...