Endocrine Abstracts

Collectively, typical and atypical lung carcinoids are referred to as the well differentiated lung neuroendocrine cancers (pulmonary NETS). Pulmonary NETS account for only 2% of lung malignancies, however, account for 25% of the total NET presentations. The incidence and prevalence of these cancers is growing. Most pulmonary NETs tend to be localised at presentation and, therefore, amenable to surgical resection. Following surgical resection, there is very little evidence base...

The incidence and prevalence of well-differentiated Bronchial NETs has been increasing globally in recent years. This may be due to better diagnostic/detection techniques and a greater awareness of these conditions. Despite this, these cancers are still uncommon and therefore most clinicians will not manage many of these patients. As a consequence, gaining experience in treating these cancers can become challenging. In the absence of a move to centralise their care, guidelines...

Well differentiated lung neuroendocrine tumours (WD lung NETS) are common NETs accounting for 25% of all the presenting neuroendocrine tumours. However, they are classified differently compared to GEP NETs, their mode of presentation; pattern of metastatic spread; associated syndromes, and how they respond to therapies are different from GEP NETs. They even present to a different group of specialists (respiratory physicians and thoracic surgeons) whereas the GEP NET patients t...

Multiple Endocrine Neoplasia Type 1(MEN1) syndrome is commonly associated with the three ’P’s-pituitary, parathyroid and pancreatic lesions. However, increasingly, thoracic neuroendocrine tumours (NETs) are being recognised with the syndrome. We present a case of MEN1 syndrome who primarily presented with a lung carcinoid tumour. A 31-year-old lady with without a significant past medical history presented with 2-month history of a persistent cough. ...

Introduction: Close long-term follow-up of patients with pulmonary carcinoid (PC) tumours is important for detection of recurrence, which can occur many years after primary surgery. Expert consensus guidelines for management of PC were published in 2015 (European Neuroendocrine Tumor Society (ENETS)) and provide recommendations for follow-up type, frequency and duration. The LEAP Project aimed to describe current follow-up practices in the UK following publication of the guida...

A 30 year old female presented with recurrent episodes of collapse with hypotension. She had been taking tramadol 100 mg four times daily for pain due to endometriosis. A random cortisol of 110 nmol/L led to suspicion of opiate induced adrenal insufficiency and further investigations were undertaken. Results 09:00 hours ACTH 3.2 ng/L, cortisol 109 nmol/L, fT4 12.3 pmol/L, fT3 3.7 pmol/L, TSH 1.18 mU/L, FSH 6.8 IU/L, LH 12.1 IU/L, prolactin 438 mU/L a...

A 30 year old female presented with recurrent episodes of collapse with hypotension. She had been taking tramadol 100 mg four times daily for pain due to endometriosis. A random cortisol of 110 nmol/L led to suspicion of opiate induced adrenal insufficiency and further investigations were undertaken. Results 09:00 hours ACTH 3.2 ng/L, cortisol 109 nmol/L, fT4 12.3 pmol/L, fT3 3.7 pmol/L, TSH 1.18 mU/L, FSH 6.8 IU/L, LH 12.1 IU/L, prolactin 438 mU/L a...

: In the present study we hypothesized that maternal thyroid disorders may be associated with maternal and foetal morbidity and mortality. The present study included 136 pregnant women selected randomly in first trimester and observed throughout the pregnancy till birth. The assessment of thyroid hormones showed a total of 33.08% (n=45) pregnant ladies were having thyroid disorders; 17.65% (n=24) with hypothyroidism and 15.44% (n=21) with hyperthyroi...

A 64-year-old woman presented acutely with dry cough, difficulty in eating, diarrhoea and weight loss. Her past medical history included cervical carcinoma in situ treated with laser therapy. She was found to be hypercalcaemic, with a corrected calcium of 2.84 mmol/l. During admission, the calcium ranged between 2.8-3.87 mmol/l. The PTH ranged between 0.2-0.4 pmol/l (1.3-9.3 pmol/l). She had raised inflammatory markers and deranged liver function tests. On review, she...

Case history: A 74 years old lady with background of hypertension and asthma had multiple admissions with funny turns, dizziness and double vision for at least 2 years. She was seen by various medical specialties including cardiology, stroke medicine and rheumatology before she was noticed to have a capillary glucose of 1.2 mmol/l. Whipple’s triad was demonstrated during evaluation. Supervised fasting confirmed biochemical evidence of endogenous hyperinsulinaemia with ina...