Searchable abstracts of presentations at key conferences in endocrinology

ea0041s8.2 | Primary aldosteronism | ECE2016

Revised guidelines for finding and treating primary aldosteronism

Mantero Franco

Primary aldosteronism is an endocrine form of hypertension which is highly prevalent among hypertensive population but its rate of detection is far lower than its real prevalence.This might be due to lack of adequate information or expertise in general practitioners or even among hypertension specialists, other than endocrinologists. As PA is common, and has a much higher cardiovascular risk profile than age-, sex-, and blood pressure (BP)–matched e...

ea0016me5 | (1) | ECE2008

How valid is a biochemical diagnosis of chromaffin tumors?

Mantero Franco

Phaeochromocytoma (PH) and functional paraganglioma (FPGL) are neoplasm of chromaffin tissue that synthesise catecholamines and are mostly located in adrenal medulla (PH) or elsewhere (FPGL). Patients may also harbour non-secreting head and neck paragangliomas (PGL). Up to ¼ of PH/PGL are familial. A high degree of suspicion for PH and FPGL should be risen in case of spells, resistant hypertension, family history of PH/PGL, a genetic syndrome that predispose to PH (e.g. M...

ea0016p148 | Clinical cases | ECE2008

A case of hungry bone syndrome during therapy with methimazole for hyperthyroidism

Sanguin Francesca , Camozzi Valentina , Mantero Franco , Luisetto Giovanni

We describe a case of severe hypocalcemia after methimazole treatment for Graves disease, which closely resembles classic hungry bone syndrome.A 41-year-old woman with a history of Graves disease presented to our Internal Medicine ward with tachyarrythmia. Laboratory data showed a severe hyperthyroidism, an ecocardigraphy demonstrated a dilated cardiomyopathy. The patient was given beta-blockers, low molecular weight heparin, and methimazole (30 mg/day)....

ea0035p12 | Adrenal cortex | ECE2014

New drugs switching off Wnt/β-catenin signaling in adrenocortical tumor cells

Rubin Beatrice , Pezzani Raffaele , Cicala Maria Verena , Iacobone Maurizio , Mantero Franco

Introduction: Adrenocortical tumors (ACT) are common diseases mostly benign, but among them, adrenocortical carcinomas (ACC) appear highly aggressive with metastatic potential. Wnt/β-catenin pathway is frequently switched on in ACT, with β-catenin greatly dephosphorylated and consequently activated. While IWR1 induces an increase in Axin2 protein levels, XAV939 inhibits tankyrase 1 and 2 (thus stabilizing Axin): both stimulate β-catenin phosphorylation and degra...

ea0029p20 | Adrenal cortex | ICEECE2012

Role of adrenal vein sampling in primary aldosteronism. Impact of different diagnostic criteria on subtype diagnosis

Cicala M. , Patalano A. , Salva M. , Miotto D. , Rubin B. , Pezzani R. , Mariniello B. , Mantero F.

In patients with primary aldosteronism (PA), adrenal vein sampling (AVS) is considered the gold standard to distinguish between unilateral and bilateral disease, while diagnostic imaging tests (CT/MRI) are often inconclusive for the diagnosis of PA. To date agreement is lacking on the best criteria indicating successful cannulation and lateralization. Aim of the study was to evaluate the impact of different diagnostic criteria for the successful cannulation and lateralization ...

ea0029p40 | Adrenal cortex | ICEECE2012

The Wnt/Beta-catenin and Ras/Raf/MEK/ERK signaling pathways alterations in adrenocortical tumors

Rubin B. , Pezzani R. , Barollo S. , Mariniello B. , Salva M. , Iacobone M. , Fassina A. , Mantero F.

Adrenocortical tumors (ACT) include benign and malignant tumors. Adrenocortical carcinomas (ACC) are highly malignant neoplasms with a poor prognosis, but their genetic alterations to date identified are limited. Laboratory studies on ACT have revealed a wide variety of signaling pathways involved in these tumors, among these Wnt/β-catenin signaling pathway and Ras/Raf/MEK/ERK pathway resulted often disregulated. Another important factor in many signaling pathways is the ...

ea0029p143 | Bone & Osteoporosis | ICEECE2012

Glucocorticoid - treatment in the adrogenital syndrome due to deficit of 21-hydroxylase: long-term bone side effects

Camozzi V. , Scaroni C. , De Toni P. , Albiger N. , Zaninotto M. , Mantero F. , Luisetto G.

The purpose of this study was to compare bone mineral density (BMD) and bone metabolism in patients suffering from adrogenital syndrome due to deficit of 21-hydroxylase with those of a group of healthy subjects. A longitudinal follow-up was also carried out in a subgroup of patients.Thirty-eight patients 19-47 years old were compared with a group of healthy, age- and sex-matched controls. Sodium, potassium, calcium, phosphorus, parathyroid hormone (PTH),...

ea0029p825 | Endocrine tumours and neoplasia | ICEECE2012

Ouabain as an antiproliferative agent on adrenocortical cell models and on primary adrenocortical tumor cells

Pezzani R. , Rubin B. , Barollo S. , Redaelli M. , Mucignat-Caretta C. , Mantero F.

Ouabain is a cardiotonic steroid belonging to Strophanthus species. Recently its role in the treatment of tumors has been investigated, as ouabain seems to exert antiproliferative effects. Adrenocortical carcinoma (ACC) is a rare cancer, with poor prognosis, of which SW13 and H295R cells could be considered a cellular model.Our aim was to evaluate if ouabain exerts anticancer property.The effects of ouabain were assessed by MTT ass...

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...