Searchable abstracts of presentations at key conferences in endocrinology

ea0032p215 | Clinical case reports – Pituitary/Adrenal | ECE2013

Follicle-stimulating hormone-secreting pituitary macroadenoma: a rare cause of abnormal menstrual cycles in a teenage girl

Arici Birsen , Motov Stefan , Kelly Christopher , Zulewski Henryk , Mariani Luigi

Introduction: Gonadotroph adenomas usually present as clinically non-functioning sellar masses. They are extremely infrequent in children. Only some case report of children and adolescents with clinical manifestations of high serum gonadotrophin levels have been published. As in adult patients most of the gonadotroph adenomas have a silent growth, and therefore a late presentation as macroadenoma with mass effects.Case report: This 16-year-old girl prese...

ea0049gp168 | Obesity | ECE2017

Effects of short sleep duration on energy metabolism and energy balance in subjects with overweight and obesity

Poggiogalle Eleonora , Donini Lorenzo , Gnessi Lucio , Mariani Stefania , Calabretto Marianna , Luisi Federica , Lenzi Andrea , Lubrano Carla

Introduction: The chronic reduction of sleep duration is associated to an increased risk of weight gain, but mechanistic aspects remain to be fully elucidated. The aim of our study was to examine the relationship between short sleep duration and energy metabolism, fuel selection and energy balance in overweight and obesity. Methods: Inclusion criteria were: age 18–65 years, BMI ≥25 kg/m2. Use of any CNS medications, any psychiatric disorders and night shi...

ea0049ep986 | Pituitary - Clinical | ECE2017

Long-term impact of primary medical and surgical therapy on bone density in men versus women with prolactinomas

Andereggen Lukas , Frey Janine , Andres Robert , El-Koussy Marwan , Beck Jurgen , Mariani Luigi , Christ Emanuel

Purpose: The prevalence of pathological bone densities in men and women with prolactinomas treated either primary surgically or medically are infrequently reported across large cohorts. In the present study, we aimed at comparing the impact of either therapeutic approach on the bone density in men vs women with prolactinomas.Methods: Retrospective case-note study including all consecutive patients with prolactinomas in whom osteodensitometry data was ava...

ea0029p882 | Endocrine tumours and neoplasia | ICEECE2012

Radioguided cortical-sparing approach for recurrent pheocromocytoma/paragangliomas

Donatini G. , Iacconi P. , Bernini G. , Boni G. , Manca G. , Spinelli C. , Mariani G. , Miccoli P.

Background: A 27-years-old women affected by recurrent pheocromocytoma/paragangliomas. We describe the evolution of disease and the surgical approach. The patient underwent a two-steps bilateral adrenalectomy for pheocromocytoma. At 15 years she underwent a left adrenalectomy. At 19 a right adrenalectomy+removal of paracaval paraganglioma were performed. After 8 years of good health she experienced again headache, tachycardia and hypertension not responsive to therapy. A diagn...

ea0081p342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

IGF1-zSDS in patients suffering from obesity with or without metabolic syndrome: a cross-sectional study in 2032 subject

Masi Davide , Risi Renata , Tozzi Rossella , Gangitano Elena , Curreli Mariaignazia , Watanabe Mikiko , Mariani Stefania , Gnessi Lucio , Lubrano Carla

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

ea0016p322 | Endocrine tumours | ECE2008

Effect of Ginkgo biloba extract supplementation on genotoxic damage after thyroid remnant ablation by 131I

Dardano Angela , Ballardin Michela , Traino Claudio , Caraccio Nadia , Colato Chiara , Barale Roberto , Mariani Giuliano , Ferdeghini Marco , Monzani Fabio

Background: Radioiodine (131I) therapy is performed in patients with differentiated thyroid cancer (DTC), either for thyroid remnant ablation or treating distant metastasis. Although 131I therapy is generally considered safe, a genotoxic damage has been demonstrated both in vivo and in vitro.Aim: To evaluate the possible effect of Ginkgo biloba extract (EGb 761) supplementation on the time-course (up to 1...

ea0081p103 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The crosstalk between adiposity and bone: a potential role for SIRT1 and sclerostin

Tozzi Rossella , Masi Davide , Cipriani Fiammetta , Elena Spoltore Maria , Contini Savina , Watanabe Mikiko , Basciani Sabrina , Lubrano Carla , Gnessi Lucio , Mariani Stefania

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

ea0081p142 | Pituitary and Neuroendocrinology | ECE2022

Chondrosarcoma of the cavernous sinus treated with postoperative proton radiation therapy: case report and endocrinological follow up after 36 months

Masi Davide , risi renata , balena angela , caputi alessandra , elena spoltore maria , rossetti rebecca , watanabe mikiko , Tozzi Rossella , Gangitano Elena , mariani stefania , Lenzi Andrea , gnessi lucio , lubrano carla

Case Summary: In May 2018, a 22-year-old man was admitted to the Emergency Room of Polyclinic Umberto I Hospital of Rome, because of progressive headaches and binocular diplopia. Brain MRI revealed a heterogeneous T1WI-hypointense and T2WI-hyperintense mass of 40x28x25 mm (CC, LL, AP) including calcification areas in the left paramedian region of the clivus invading the homolateral cavernous sinus. The patient underwent partial tumour resection via infratemporal approach and a...

ea0090ep1108 | Late Breaking | ECE2023

Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight. Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight

Tozzi Rossella , Garcia Delgado Yaiza , Maria Sanchez Hernandez Rosa , Gil Quintana Yaiza , Hernandez Hernandez Diego , Davila Veronica , Boronat Mauro , Mariani Stefania , Gnessi Lucio , Maria Claudia Wagner Anna

Background and aim: Dual energy X-ray absorptiometry (DXA) is considered the gold standard to evaluate BC, even if it requires the use of radiations, an expensive equipment and cannot be performed at the patient’s bedside. Nutritional ultrasound (NU) evaluates BC through the assessment of muscle mass and the abdominal subcutaneous (superficial and deep-layer) and visceral adipose tissue. We aimed at comparing the accuracy and reliability of this emerging tool with DXA in ...

ea0063gp141 | Obesity | ECE2019

Dietary inflammatory index is differently associated with ectopic fat depots in overweight and obese adults

Poggiogalle Eleonora , Lubrano Carla , Luisi Federica , Hebert James R , Shivappa Nitin , Di Martino Michele , Gnessi Lucio , Mariani Stefania , Lenzi Andrea , Donini Lorenzo M.

Introduction: In overweight and obesity energy unbalance is responsible for the accumulation of ectopic fat. Excess energy and metabolic alterations, namely insulin resistance, may favor ectopic fat depositions. However, the role played by dietary factors, especially the pro-inflammatory properties of dietary patterns, in ectopic fat storage is not thoroughly understood. The aim of our study was to investigate the association between the Dietary Inflammatory Index (DII) and di...