Endocrine Abstracts

The incidence of obesity has dramatically increased, not only in industrialized societies but also in developing countries. Since male fertility shows a parallel decrease, obesity should be considered as possible etiology of male subfertility.Studies exploring this possible association report that obesity may affect fertility by different mechanisms that include: abnormal reproductive hormonal milieu, increased release of adipokines and adipose-derived h...

Background: Dysnatremia is common in hospitalized patients, often worsening the prognosis in pneumopathies and critical illnesses, such as COVID-19. Here, hyponatremia is an indicator of pulmonary involvement, while hypernatremia is associated with worse assistance outcomes, particularly when resulting from an overcorrected hyponatremia. Longer hospitalizations, readmissions after discharge and higher short- and long-term mortality rates have been observed in acute patients ex...

Introduction: LDL cholesterol (LDL-C) is usualy estimated using the Friedewald equation. This equation assumes a fixed factor of 5 for the ratio of triglycerides to very LPL cholesterol (TG:VLDL-C); however, the actual TG:VLDL-C ratio varies significantly across the range of triglyceride and cholesterol levels. A new method was proposed by Martin, S and co-workers using NHANES data. We aimed to evaluate the concordance Friedewald formula with the new method for LDL-C estimatio...

Context: Childhood gender dysphoria, when not attenuating after the onset of puberty, is very likely to persist. The aim of puberty suppressing therapy in gender dysphoric adolescents is increasingly shifting from ‘buying time to reflect on the diagnosis’ towards ‘avoiding the development of secondary sexual characteristics while awaiting eligibility for cross-sex hormones’. Various treatment regimens are available to suppress or decrease the effects of end...

Men and women who have AIS face a number of challenges. Based on research insights from the past two decades, management of this pleiotropic condition during childhood has totally changed. In this presentation, we will update endocrinologists who provide care for adults living with AIS about these changes, as they will, after transition, need to further counsel their patients and coordinate multidisciplinary care and surveillance of retained gonads in adulthood. Girls with com...

The incidence of diabetes, a disease characterized by high blood glucose levels, is increasing worldwide. Besides the well-known complications of diabetes including cardiovascular disease, retinopathy, nephropathy, and neuropathy, also bone fragility has recently been recognized as a complication of diabetes. In fact, type 1 diabetes is associated with a 6-fold increase in hip fractures with a marked loss of bone mineral density, while type 2 diabetes is associated with a 1.5-...

Skeletal lesions are a frequent complication of breast and prostate cancer. At present, 60–80% of patients with breast or prostate cancer develop bone metastases, which frequently result in skeletal-related events, including pathological fractures, pain, and neurological syndromes that require surgery or radiotherapy, and reduce quality of life. Autocrine and paracrine factors modulate various aspects of bone metastasis, including tumor proliferation, epithelial-to-mesenc...

Current therapies for acromegaly are unsatisfactory for some patients. High dose thiazoledinedines have been reported to shrink tumor size and reduce serum GH levels in animal models of acromegaly. To study the effects of increasing doses of rosiglitazone on serum GH and IGF1 concentrations in acromegalic patients, we designed a phase two clinical trial. We enrolled five consecutive patients with active acromegaly uncontrolled under conventional therapies. They received increa...

IntroductionNeurological complications related to COVID-19 are described. The pituitary expresses ACE which is known as the entrance for Sarscov2 through binding to viral S-protein. Pituitary apoplexy (PA) is due to the sudden hemorrhagic infarction of pre-existing pituitary tumors or the gland itself and its symptoms and radiological findings can be similar to acute hypophysitis (AH) caused by viral infections.Subjects and methods...

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further information on the prize can be found at http://www.ese-hormones.org/prizes/eje.aspx. This year’s recipient is Prof. Martin Fassnacht. The prize will be presented as part of the ECE 2014 opening ceremony where ...