Searchable abstracts of presentations at key conferences in endocrinology

ea0011s28 | Novel peptides in reproduction | ECE2006

A genomic analysis of polypeptide ligands and receptors: the example of relaxin and LGR families

Hsueh A , Kawamura K , Luo C , Mazerbourg S , Kumagai J , Avsian-Kretchmer O , Rauch R , Ben-Shlomo I , Yu Hsu S

The availability of genome sequences from humans and multiple model organisms has facilitated the identification of many human plasma membrane receptor families and allowed the analysis of their phylogeny. We traced the evolution of known families of human plasma membrane receptors for inclusion in the Human Plasma Membrane Receptome database at http://receptome.stanford.edu (Science STKE. 2003). Using an evolutionary approach, we identified new polypeptide hormones and recept...