Endocrine Abstracts

Background: There is limited data on the use of Denosumab for hypercalcaemia in patients with primary hyperparathyroidism (PHPT). We describe a case of severe hypercalcaemia in a critically ill patient with COVID, on a background of mild PHPT prior to hospital admission.Case report: Seventy-seven-year-old gentleman with mild hypercalcaemia dating back to 2019, was referred to endocrinology with hypercalcaemia (adjusted calcium 4.02 mmol/l) and associated...

Introduction: Acute adrenal insufficiency (adrenal crisis) is a life-threatening condition caused by glucocorticoid deficiency. Patient and carer education is key in the prevention, early identification and prompt management of this condition. We assessed the knowledge of adrenal insufficiency/crisis in patients with adrenal and pituitary disease to evaluate the strengths and weaknesses of local ‘sick day’ education processes.Methods: We utilis...

A 73-year-old female with previous tuberculosis, primary hypothyroidism, depression and caecal cancer was referred to Endocrinology when interval CT scanning reported a 2.5 cm adrenal mass, stable in size over 4 years. No symptoms or signs of hormonal production were noted. Screening tests were abnormal: post-1 mg dexamethasone cortisol was 98 nmol/l, 24-h urinary free metadrenaline was elevated tenfold (3256 nmol/24 h, range 0–350) to a concentration reported to have hig...

A 31 year old female with no prior history of thyroid disease presented to hospital four days after 2nd dose Pfizer vaccination with fever, myalgia, neck discomfort and chest pain; which was relieved by sitting forwards. A small goitre and tachycardia were noted on physical examination. CXR and echocardiogram were normal. ECG revealed sinus tachycardia. Troponin T was elevated (32 ng/l, normal <5). Free T4 was raised (26.6 pmol/l, reference 10-22) with an undetectable TSH ...

Introduction: The number of children with type 1 diabetes continues to rise by 3% per year. As part of an audit of in-patient care of children up to 16 years with diabetes, the guidelines for management of the newly diagnosed children from participating hospitals were reviewed and compared to national and international recommendations.Methodology: Across the Oxford, Wessex and South West Paediatric Diabetes Networks 21 out of the 27 requested services su...

Objective: In humans insulin-induced hypoglycaemia activates the autonomic nervous system and provokes counterregulatory hormonal responses, the magnitude of which is lower in healthy non-diabetic females and in women with type 1 diabetes compared to male counterparts, although the glycaemic thresholds at which these responses are triggered are similar in both sexes. The Edinburgh Hypoglycaemia Score (a validated method of symptom assessment) was used to examine symptoms to as...