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ea0011p413 | Diabetes, metabolism and cardiovascular | ECE2006

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with altered circulating IGF-I and lower body mass index in type-2 diabetes mellitus

Heald AH , Stephens RH , McElduff P , Kaushal K , Siddals K , New JP , Worthington J , Ollier WE , Gibson JM

Introduction: Dysregulation of the insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF binding protein-1 (IGFBP-1) has been implicated in the pathogenesis of obesity, diabetes mellitus and its complications such as cardiovascular disease and nephropathy, but relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP-1 gene, in a r...

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ea0011p414 | Diabetes, metabolism and cardiovascular | ECE2006

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with increased type-2 diabetes mellitus prevalence

Heald AH , Stephens RH , McElduff P , Kaushal K , New JP , Worthington J , Ollier WE , Pendleton N , Horan M , Payton A , Gibson JM

Introduction: Dysregulation of the Insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF-binding protein 1 (IGFBP-1) has been implicated in the aetiopathogenesis of obesity, diabetes mellitus and such complications such as cardiovascular disease and nephropathy. However, relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP1...

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Endocrine Abstracts

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with altered circulating IGF-I and lower body mass index in type-2 diabetes mellitus

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with increased type-2 diabetes mellitus prevalence

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