Searchable abstracts of presentations at key conferences in endocrinology

ea0019p112 | Cytokines and growth factors | SFEBES2009

Lack of short term catch up growth in children with Crohn's disease treated with infliximab

Wong SC , Malik S , Russell RK , McGrogan P , Ahmed SF

Background: Recent studies show that Infliximab (IFX), an antibody against tumour necrosis factor α (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13 M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months be...

ea0017p6 | (1) | BSPED2008

Suboptimal linear growth despite entry into puberty in children with inflammatory bowel disease

Wong SC , Mason A , Russell RK , McGrogan P , Ahmed SF

Background: Growth retardation and pubertal delay is frequently encountered in children with inflammatory bowel disease (IBD). There are currently no published data on sitting height (SH), subischial leg length (SILL)and growth rates in relation to pubertal status in these children.Objective: To assess skeletal disproportion and growth rates in children with IBD.Methods: Retrospective study of 40 children (32M):35 Crohn’s dise...

ea0017p8 | (1) | BSPED2008

Lack of short-term catch up growth in children with Crohn's disease treated with infliximab

Wong SC , Malik S , Russell RK , McGrogan P , Ahmed SF

Background: Recent studies show that infliximab (IFX), an antibody against tumour necrosis factorα (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months befo...

ea0017p14 | (1) | BSPED2008

Growth and pubertal status following pubertal induction in boys with IBD

Mason A , Wong S , Russell R , McGrogan P , Ahmed S

Background: Children with inflammatory bowel disease (IBD) may suffer from growth and pubertal delay.Objective: To assess pubertal status and growth in a group of boys with IBD before (T+0) and 6 months after (T+6) initiation of testosterone therapy.Methods: Retrospective study of boys with IBD undergoing pubertal induction. Height (Ht) and pubertal status were obtained at T+0 and T+6. Markers of disease activity and data on concom...

ea0036oc4.8 | Oral Communications 4 | BSPED2014

Recombinant human GH in paediatric inflammatory bowel disease: short term effects on bone biomarkers and long term effects on bone and lean mass

Altowati M A , Shepherd S , McGrogan P , Russell R K , Wong S C , Ahmed S F

Background: Recombinant human GH (rhGH) may improve bone mass in paediatric inflammatory bowel disease (IBD).Objective: To investigate rhGH on bone and body composition in paediatric IBD.Method: Bone biomarkers were evaluated in 12 children, 11CD (10M), median age 14.4 year (8.9, 16.2) who received rhGH (0.067 mg/kg per day) as part of a 6 months RCT. Eight received rhGH for 24 months and had DXA evaluation. Results were reported a...

ea0030p61 | (1) | BSPED2012

A prospective study of pubertal growth in children with inflammatory bowel disease

Mason Avril , Malik Salma , McMillan Martin , McNeilly Jane , Bishop Jonathan , McGrogan Paraic , Russell Richard , Ahmed Faisal

Background: Puberty is understood to be commonly affected in adolescents with Crohn’s disease (CD) and ulcerative colitis (UC).Objective: To determine the impact of IBD on pubertal status and pubertal growth.Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and b...

ea0027p10 | (1) | BSPED2011

A longitudinal study of pubertal growth in inflammatory bowel disease

Mason A , Russell R K , Bishop J , McGrogan P , MacIntyre H E , Ahmed SF

Background: Delayed puberty and related problems with growth and body image in Crohn’s disease (CD) and ulcerative colitis (UC) have rarely been quantified.Methods: A longitudinal prospective observational study of children with IBD who had anthropometric and puberty data at 0 and 6 months. Of 50 recruited, there were 15 boys (CDM) and 20 girls (CDF) with CD and ten boys (UCM) and five girls (UCF) with UC. The four groups had a median age at 0 month...

ea0024p23 | (1) | BSPED2010

The impact of inflammatory bowel disease on pubertal growth is most marked in boys with Crohn’s disease

Mason A , Malik S , Russell R K , Bishop J , McGrogan P , Ahmed S F

Background: Puberty is understood to be commonly effected in adolescents with Crohn’s Disease (CD) and ulcerative colitis (UC). However, the extent of this effect and related problems with growth, have rarely been quantified.Objective: To determine the impact of CD and UC on pubertal growth.Methods: Retrospective study of 148 children with IBD (casenotes available, 135) who fulfilled the criteria for describing growth spurt pa...

ea0023p9 | (1) | BSPED2009

Improvement in growth of children with crohn's disease following anti-TNFα therapy can be independent of pubertal progress and glucocorticoid reduction

Malik Salma , Wong Jarod , Bishop Jonathan , Hassan Kamal , McGrogan Paraic , Russell Richard , Ahmed Faisal

Introduction: Treatment with anti-TNFα therapy such as infliximab may improve growth in children with CD but the extent of improvement in growth and its relationship to pubertal progress and changes in glucocorticoid therapy are unclear.Aim: A retrospective study of growth, puberty and disease activity over the 6 months prior (T−6) to starting infliximab, at baseline (T0) and for the following 6 months (T+6) in CD. Results are expressed as med...

ea0021p228 | Growth and development | SFEBES2009

Delayed puberty in children with inflammatory bowel disease may be associated with gonadotrophin resistance

Wong Jarod , Mason Avril , Russell Richard , McGrogan Paraic , Bishop Jonathan , Ahmed Faisal

Background: The aetiology of delayed puberty in children with inflammatory bowel disease (IBD) is unclear.Methods: Retrospective analysis of 27 children with IBD with growth retardation and/or pubertal delay, who had basal LH and FSH (27) and LHRH stimulation test as part of clinical evaluation (25). Height velocity was converted to SDS for bone age for girls >11 years and boys >12 years to adjust for delayed puberty. Data expressed as median (ra...