Endocrine Abstracts

By including the synthetic glucocorticoid (GC), dexamethasone, in the maternal drinking water on gestational days 16–19 (0.5 μg/ml) or days 1–7 after birth (1.0 μg/ml), we have recently demonstrated (McArthur et al. J. Neuroendocrinol. 17: 475) that perinatal exposure of rat pups to GCs increased dopaminergic (DA) cell numbers in the adult ventral tegmental area (VTA) at −5.1 to −5.4 mm relative to Bregma (level I). In order to investig...

Myotonic Dystrophy is an autosomal dominant multi-system disorder characterised by muscle weakness and myotonia, with associated cardiac, ophthalmic, gastrointestinal and endocrine abnormalitiesA 16-year-old boy was referred with a 2 months history of difficulty releasing his hand-grip and problems with swallowing. The clinical diagnosis of myotonic dystrophy 1 was confirmed with genetic testing with the detection of a DMPK expansion mutation. During inv...