Searchable abstracts of presentations at key conferences in endocrinology

ea0011p248 | Cytokines and growth factors | ECE2006

Proinflammatory cytokine gene expression shows intrinsic circadian oscillation in peripheral cells

McMaster A , Lebiecki J , Loudon A , Donn R , Ray DW

An extraordinary array of behavioural and physiological systems is regulated by endogenous circadian timekeepers within mammals. This circadian machinery is comprised of intricate autoregulatory transcription feedback loops, which interact to generate a time delay of approximately 24 hours in the cyclical transcription of components. In addition to the master clock in the suprachiasmatic nucleus it is clear that peripheral tissues also express clock components. The central clo...

ea0081rc4.7 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

The burden of pain in patients with acromegaly

Kreitschmann-Andermahr Ilonka , Kahl Annalena , Deutschbein Timo , Honegger Jurgen , Unger Nicole , Detomas Mario , Giese Sabrina , Schroeder Bernadette , Chmielewski Witold , Siegel Sonja

Introduction: The aim of the present study was to explore pain prevalence, pain locations and its impact on everyday activities and health-related quality of life (QoL) in a large cohort of patients with acromegaly.Methods: We conducted a survey at three major centers specialized on the treatment of pituitary diseases. 124 patients with acromegaly (mean age 56.6y ± 13.5) filled in a self-constructed questionnaire on acromegaly symptoms, pain includi...

ea0065p248 | Metabolism and Obesity | SFEBES2019

Using problem-based learning (PBL) to engage undergraduate medical students in endocrinology at Edinburgh Medical School

Pender Frederic T , Morley Steven D

Background: Endocrinology, taught in Year 2 of the Edinburgh undergraduate MBChB curriculum to approximately 200 medical students, can present a complex challenge and a test of engagement. Core biomedical curriculum content is delivered as large group teaching (lectures) and then revisited in smaller groups (clinical-cased based tutorials, PBL) designed to integrate learning by applying basic knowledge in a clinical context. PBL first implemented in the 1960s at McMaster Unive...

ea0070aep122 | Bone and Calcium | ECE2020

Phase 3b open-label study of burosumab in adults with X-linked hypophosphatemia (XLH): Baseline and Week 12 results

Kamenický Peter , Javaid Kassim , Keen Richard , Lachmann Robin , Ralston Stuart , Cohen-Solal Martine , Brandi Maria , Briot Karine , Crowley Rachel , Walsh Jennifer , Kolta Sami , Rylands Angela , Sun Wei , Nixon Annabel

Introduction: Burosumab, a fully human monoclonal antibody to fibroblast growth factor 23 (FGF23), is the only approved treatment for XLH, a rare genetic disorder characterized by renal phosphate wasting and substantial cumulative musculoskeletal morbidity. BUR02 (NCT03920072) is a European phase 3b open-label study monitoring the long-term safety and efficacy of burosumab in adults with XLH from sites who participated in the CL303/CL304 studies (NCT02526160/02537431).<p c...