Endocrine Abstracts

Introduction: Acromegaly is a chronic endocrine disorder caused by excess growth hormone (GH) secretion. Hypersecretion of GH causes increased IGF-1 secretion from the liver which in turn leads to a series of multisystemic complications including somatic overgrowth and multiple comorbidities.Case report: Thirty-nine-year-old female patient was seen in ophthalmology outpatient clinic with the complaint of a mass inside the right upper eyelid. On ophthalmo...

Mitogen-activated protein kinases (MAPK) are a family of serine/threonine kinases and are key signaling pathways involved in the regulation of normal cell proliferation, survival and differentiation. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated protein kinases (ERK1 and 2); c-Jun N-terminal kinases (JNK1-3); p38s (α, β, γ, δ) and ERK5. Aberrant regulation of MAPK cascades contribute to cancer and ...

A 71-year-old hypertensive and diabetic male patient was seen in the outpatient clinic for routine control. On laboratory examination his serum potassium level was 5.76 mmol/l and serum sodium level was 135 mmol/l. Control serum potassium level was 5.7 mmol/l. In past medical history he was prescribed telmisartan/hydrochlorothiazide combination (80 mg/12.5 mg) 1 month ago for treatment of hypertension. His other medications included nifedipine, fluvastatin sodium, aspirin, pio...

Background: Transsphenoidal surgery of pituitary adenoma is often first-line therapy for patients with acromegaly. Pharmacotherapy and/or radiotherapy are applied when surgery fails to achieve good disease control, or when surgery is impossible or contraindicated. In this study, we report the results of therapies, rates of cure and hypophyseal insufficiency in our acromegalic patients.Methods and results: Medical files of the 62 patients who were followe...

Hypothyroidism is a common endocrine disorder which is easily treatable by an appropriate thyroid hormone replacement therapy in the majority of patients. In some patients, hypothyroidism is refractory to oral levothyroxine substitution. Common causes of lack of response to levothyroxine replacement comprise non-compliance and impaired absorption. We report a case of pseudomalabsorption of levothyroxine. Here, we report two female patients with hypothyroidism who had multinod&...

Objective: Nonfunctional adrenal masses are a risk indicator of increased cardiometabolic risk. Especially; increased thrombogenic ambient, insulin resistance, hepatosteatosis and abdominal obesity are determined in these patients with nonfunctional adrenal masses. Our purpose was to show the association of adrenal incidentalome and metabolic syndrome in consideration of the studies and to detect the increase in the carotid intima-media thickness which is regarded as the prece...

Introduction: Primary aldosteronism is presented with signs of hypertension and hypokalaemia classically, however, primary adrenal carcinoma is very rare condition. We aimed to present a patient with a metastatic adrenal carcinoma after the primary diagnosis of hyperaldosteronism.Case report: A 46 years old male patient was referred to our hospital with weakness, dry mouth and weight loss. He had lost weight as 31 pounds during last 3 months. Physical ex...

Introduction: Acromegaly is a very rare disease with persistent GH secretion due to excessive release of liver IGF1. The risk of malignancy, particularly colon cancer, is increased in acromegalic patients. But no evidence is found in the literature associated increasing of laryngeal carcinoma in acromegalic patients. We aimed to present this case that laryngeal carcinoma should be considered in acromegaly by the clinicians.Case report: A 51-year-old male...

Introduction: Obesity prevalance is rapidly increasing all over the world and become a serious health problem. There is a significant correlation between serum calcium levels and body fat mass. It was indicated that when plasma calcium levels increase, BMI decrease however, insulin, total cholesterol, and triglycerides levels increase. In this study, it was investigated the relationship between plasma calcium levels and cardiovascular risk factors and metabolic syndrome parame...

Background: Acromegaly is a relatively rare endocrine disorder which may result in morbidity and mortality. In this study, we report the demographical and clinical characteristics of 62 acromegalic patients who were followed-up at our Department of Endocrinology Clinic.Methods and results: In this retro-prospective study, medical files of the patients who were followed-up from 1984 to 2013 were examined. Data was obtained for age at the time of diagnosis...