Searchable abstracts of presentations at key conferences in endocrinology

ea0084op-13-65 | Oral Session 13: Basic 3 | ETA2022

3,3’,5-triiodo-l-thyronine and 3,5-diodo-l-thyronine differentially modulate hepatic mitochondrial quality control in hypothyroid rats

Giacco Antonia , Petito Giuseppe , Mercurio Giovanna , Magnacca Nunzia , Senese Rosalba , Silvestri Elena , Cioffi Federica

Objective: The maintenance of healthy and functional mitochondrial network via mitochondrial quality control (QC) mechanisms, is critical throughout life to respond to physiological adaptations and stress. Due to their role in energy production, mitochondria are exposed to high amounts of reactive oxygen species making their DNA (mtDNA) particularly vulnerable to oxidative damage. Mitochondrial dysfunction causes altered QC mechanisms (i.e. altered biogenesis, dynamics, autoph...

ea0011p89 | Clinical case reports | ECE2006

A case of adult GH deficit in a woman with Autoimmune Polyendocrine Syndrome type II

Pietrobono D , Bassotti G , Diacono F , Iuorio R , Mercuri V , Gargiulo P

We report a case of a 53 years old woman who presented asthenia, cramps, cutaneous hyperpigmentation, nausea, vomiting, vague and non-specific epigastric abdominal pain, weight loss and hypotension. She was diagnosed with Addison’s disease because biochemical data were indicative for autoimmune adrenal failure (positivity for adrenal cortex antibodies). Nevertheless during the following 9 years the patient began to note the progressive reduction of pubic and axillary hair...