Searchable abstracts of presentations at key conferences in endocrinology

ea0011s32 | Flies, worms and fish: use in endocrine research | ECE2006

Giant flies and more: probing the functions and genetics of insulin signalling in Drosophila

Wilson C , Meredith D , Boyd CAR , Goberdhan DCI

Defective signalling by insulin-like molecules is not only a fundamental characteristic of diabetes, but is also associated with the majority of human tumours, where signalling is typically hyperactivated. Although both these diseases have a significant genetic component, we are still some distance from identifying all the genes and cellular mechanisms affected.We and other groups use the powerful genetics of the fruit fly, Drosophila melanogaster...

ea0095p61 | Obesity 1 | BSPED2023

The use of cardiopulmonary exercise testing (CPET) for assessment and guiding interventions in adolescents with obesity

Larcombe Thomas , Davis Nikki , Meredith Tom , Connett Gary

Introduction: Paediatric obesity is increasing globally. By 2050, obesity is expected to cost the UK NHS £10 billion annually.1 Physical activity and exercise are recognised interventions to reduce BMI.2 However, the physiological response to exercise is not understood. Understanding physiological responses in people with obesity (PwO) can inform the prescription of safe rehabilitation exercise programmes. This pilot study explored t...

ea0081p562 | Calcium and Bone | ECE2022

Serum 25-hydroxyvitamin D (25(OH)D) levels in Pregnant women with gestational diabetes mellitus

Jude Edward , Mathew Susan , Heath Jennifer , Saw Denise , Meredith Kate , Krishnamurthy Roopa

Background: The importance of vitamin D supplementation in pregnancy is well known. Hypovitaminosis D is associated with adverse maternal and foetal outcomes such as pre-eclampsia, gestational diabetes mellitus, bacterial vaginosis, increased incidence of caesarean section delivery, intra-uterine growth restriction and reduced bone and muscle mass in childhood. The recommendations for vitamin D supplementation vary widely, with NICE guidelines suggesting a daily replacement do...

ea0038p401 | Steroids | SFEBES2015

Do androgens lead to increased erythropoiesis in women with congenital adrenal hyperplasia?

Karunasena Nayananjani , Elman Meredith , Mallappa Ashwini , Merke Deborah P , Ross Richard , Daniel Eleni

Background: In men there is a strong relationship between androgens and erythropoiesis; however this has not been shown in women. Patients with congenital adrenal hyperplasia (CAH) if uncontrolled may have high androgen levels and if over treated with glucocorticoids low androgen levels. Therefore CAH provides a potential model to examine the relationship between androgens and erythropoiesis in women.Aim: To investigate the relationship between androgens...

ea0034p171 | Neoplasia, cancer and late effects | SFEBES2014

Neuroendocrine biomarkers change with treatment in small cell lung cancer

Meredith Suzanne , Bryant Jennifer , Babur Muhammad , Riddell Philip , Williams Kaye , White Anne

Small cell lung cancer (SCLC) is distinguished by its neuroendocrine phenotype and secretion of hormone biomarkers. Tumours initially respond well to therapy but almost invariably relapse with a therapy-resistant phenotype. We have previously described pro-opiomelanocortin (POMC) as a potential biomarker of SCLC. In this study, we investigated how POMC acts as a biomarker of tumour response to treatment.SCLC cells (DMS 79) were injected subcutaneously in...

ea0030p38 | (1) | BSPED2012

Cushing's syndrome due to POMC secretion from an abdominal yolk sac tumour in a 2 year old child

Gevers Evelien , Shah Pratik , Meredith Suzanne , Torpiano John , Slater Olga , White Anne , Dattani Mehul

Cushing’s syndrome due to ectopic ACTH production is extremely rare in childhood. Ectopic ACTH secretion is most often due to tumours in the chest, but rare cases of carcinoid tumours, neuroblastoma, phaeochromocytoma and pancreatic and ovarian carcinoma have been reported. We describe a 2 year old girl with ectopic Cushing’s syndrome due to a malignant epithelial abdominal tumour producing POMC. She presented with rapid weight gain, hypertension, body odour, letharg...

ea0044p39 | Adrenal and Steroids | SFEBES2016

Salivary cortisone is a potential surrogate for serum cortisol measurement

Adam Safwaan , Minder Anna , Cottrell Elizabeth , Davies Alison , Meredith Suzanne , Preziosi Richard , Keevil Brian , Higham Claire , White Anne , Trainer Peter

Introduction: Hydrocortisone therapy in adrenal insufficiency and medical management of Cushing’s syndrome requires accurate monitoring of glucocorticoid status. Currently, this necessitates admitting patients to hospital for serial measurements of serum cortisol. From previous studies in Cushing’s, the goal of medical therapy is a mean (based on five samples) serum cortisol of 150–300 nmol/l, which is known to equate to a normal cortisol production rate. Saliva...

ea0044p235 | Thyroid | SFEBES2016

Hypothyroidism induces hyperplasia of unilocular adipocytes in perirenal adipose tissue of the ovine fetus

Harris Shelley E , De Blasio Miles J , Wooding FB Peter , Blache Dominique , Meredith David , Fowden Abigail L , Forhead Alison J

Thyroid hormones are important regulators of fetal growth, although their mechanism of action remains unclear. In the sheep fetus, thyroid hormone deficiency increases plasma insulin and leptin concentrations. This study investigated the effects of hypothyroidism on perirenal adipose tissue (PAT) development and adipose insulin signalling pathways in fetal sheep.All procedures were performed under the UK Animals (Scientific Procedures) Act 1986. In 10 tw...

ea0038p433 | Thyroid | SFEBES2015

Effect of hypothyroidism on pancreatic β-cell mass and circulating insulin concentration in the ovine foetus

Harris Shelley E , Blasio Miles J De , Wooding F B Peter , Fowden Abigail L , Meredith David , Forhead Alison J

Thyroid hormones are important regulators of fetal growth, although their mechanism of action remains unclear. This study investigated the effect of hypothyroidism on pancreatic β-cell development in foetal sheep.All procedures were carried out under the UK Animals (Scientific Procedures) Act 1986. Under general anaesthesia between 105 and 110 days of gestation (days; term ~145 days), one twin fetus was thyroidectomised (TX), while the other was sha...

ea0025p179 | Endocrine tumours and neoplasia | SFEBES2011

Pro-opiomelanocortin is a marker of liver and brain metastases from small cell lung cancer xenografts

Meredith Suzanne , Babur Muhammad , Begum Ghazala , Telfer Brian , Gieling Roben , Dean Emma , Dive Caroline , Williams Kaye , White Anne

Small cell lung cancer (SCLC) is highly aggressive with a particularly poor prognosis. This is due to tumours quickly metastasising and developing chemoresistance. SCLC tumours possess neuroendocrine properties in that they secrete prohormones such as pro-opiomelanocortin (POMC) and pro-gastrin releasing peptide (pro-GRP). These can be detected in the circulation and therefore have potential as biomarkers for prognosis and relapse. The aims of this study are; i) develop a mode...