Endocrine Abstracts

Pregnancy causes significant physiological changes that can alter the results of thyroid function testing. The changes in circulating plasma-binding protein (TBG) concentrations interfere with FT4 estimate methods, and the hCG thyrotropic effect impacts TSH activity estimation. A TSH assay is the most sensitive test to assess thyroid status. T4 levels have been implicated as associated with fetal neurodevelopment. During pregnancy, differences in FT4 concentrations have been d...