Searchable abstracts of presentations at key conferences in endocrinology

ea0035p787 | Obesity | ECE2014

The association between metabolic syndrome and android fat mass and android to gynoid fat mass ratio- are Classification and Regression Trees models helpful?

Brona Anna , Milewicz Andrzej

The aim of the study was to estimate thresholds of android fat mass and android to gynoid fat mass ratio at which metabolic disorders and blood pressure typical of metabolic syndrome appear. Classification and Regression Trees models were used to estimate these thresholds for glucose, HDL cholesterol, triglycerides and systolic and diastolic blood pressure.Methods: healthy postmenopausal women were recruited for the study. Blood samples were collected fo...

ea0056ep148 | Reproductive Endocrinology | ECE2018

Birth weight of children born to women with AITD compared with those born to women without AITD

Dubiel Agnieszka , Milewicz Tomasz

Aim: The aim of the study was to evaluate the birth weight of children born to women with AITD compared to with those born to women without AITD.Material and methods: The study included 596 pregnant women and their children in 2007–2015. The patients were divided into two groups. The first (group A) consisted of 191 pregnant women with chronic autoimmune thyroiditis and their children, while the second (group B) consisted of 405 pregnant women witho...

ea0035p666 | Female reproduction | ECE2014

Does polycystic ovary syndrome influence incidence nonalcoholic fatty liver disease in women?

Bohdanowicz-Pawlak Anna , Laczmanski Lukasz , Milewicz Andrzej

The aim was to assess associations among metabolic abnormalities in polycystic ovary syndrome (PCOS) and NAFLD.Materials and methods: In 184 women with PCOS and 125 healthy premenopausal volunteers sex steroids, lipids, glucose, insulin, aminotranspherases, CRP, free androgen index (FAI), HOMA and E2:testosterone were calculated. Hepatic steatosis was determined by ultrasound. The analysis of multivariate (logistic regression) due to the prese...

ea0029p1741 | Thyroid (non-cancer) | ICEECE2012

Increase of Serum Adiponectin And Stable Concentrations of Matrix Metalloproteinases Confirm Safety of Radioiodine Treatment of Thyrotoxicosis

Lewinski A. , Brona A. , Lewandowski K. , Bienkiewicz M. , Milewicz A.

Background: Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), remodel extracellular matrix under physiological and pathological conditions and are implicated in pathogenesis of cardiovascular diseases, cancer and in chronic inflammation. We have endeavoured to assess whether concentrations of MMPs, TIMPs, proinflammtory thrombospondin and anti-inflammatory adiponectin are altered by administration of radioiodine during treatment of thyrotoxicosis...

ea0049ep141 | Clinical case reports - Thyroid/Others | ECE2017

The ovarian origin of hiperandrogenism in the postmenopausal woman with the adrenal adenoma – a case report

Kialka Marta , Milewicz Tomasz , Doroszewska Katarzyna , Mrozinska Sandra , Jach Robert

Hyperandrogenism is a clinical condition characterized by excessive secretion of male sex hormones. An excess amount of androgens in women is manifested by symptoms of defeminization and masculinization. Hormonally active adrenal and ovarian tumors and non-tumor causes must be considered in the differential diagnosis. The authors describe the case of a 77-year-old patient who had hirsutism and reduction of the timbre of the voice. At the beginning she was suspected to have adr...

ea0049ep357 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Metformin and changes in blood pressure and heart rate in lean patients with polycystic ovary syndrome (PCOS)- preliminary study

Kialka Marta , Milewicz Tomasz , Klocek Marek , Tomczyk Rita

Introduction: The aim of our study was to assess the value of blood pressure and heart rate using the 24-h blood pressure monitoring (ABPM) before and after treatment with metformin to patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 20 patients received metformin 1500 mg/day in three divided doses. ABPM was performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.<p class="a...

ea0049ep890 | Neuroendocrinology | ECE2017

Metformin increases pressure pain threshold in lean PCOS women

Kialka Marta , Milewicz Tomasz , Sztefko Krystyna , Rogatko Iwona , Majewska Renata

Background: Despite the strong preclinical rationale, there are only very few data considered the utility of metformin, as a potential pain therapeutic in humans. The aim of this study was to determine, the association between metformin therapy and pressure pain threshold (PPT) in lean polycystic ovary syndrome (PCOS) women. We hypothesized that metformin therapy in lean PCOS women increases pressure pain threshold.Materials and methods: Twenty-seven lea...

ea0049ep1111 | Female Reproduction | ECE2017

Natural history of the Swyer Syndrome

Doroszewska Katarzyna , Milewicz Tomasz , Kialka Marta , Mrozinska Sandra

We present a case of a eighteen-year-old woman admitted to the Gynecological and Endocrinological Department because of primary amenorrhea. Physical examination showed excessive pubic hair and clitoral hypertrophy. Laboratory tests showed the increased level of foliculotropina (FSH) 90 mIU/ml (normal range 3.5–12.5 mIU/ml) and the estradiol level below 10 pmol/l (normal range 46–607 pmol/l). An ultrasound-imaging of the abdomen and pelvis showed the uterus of normal ...

ea0035p75 | Bone and Osteoporosis | ECE2014

What factors influenced on femoral neck bone mineral density in postmenopausal women?

Jedrzejuk Diana , Lwow Felicja , Arkowska Anna , Mieszczanowicz Urszula , Milewicz Andrzej

Postmenopausal osteoporosis is a condition that appears as a result of a sudden reduction in E2 production by the ovaries. The earliest is manifested by the reduction of lumbar BMD; mostly consisted of trabecular bone. Proximal femur is built mostly of cortical bone, and so is aging more slowly, but femoral fracture more often lead to disability and death. The aim of the study was to check which from the anthropometric, hormonal and biochemical markers have the infl...

ea0035p152 | Calcium and Vitamin D metabolism | ECE2014

The effect of VDR polymorphisms on serum testosterone level in aging men population

Laczmanski Lukasz , Lwow Felicja , Kolackov Katarzyna , Milewicz Andrzej

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...