Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc5.8 | Reproduction | ECE2008

The effect of estrogens plus cyproterone acetate or orchiectomy on serum insulin like factor 3 (INSL3) levels in transsexual men

Maione Luigi , Palmieri Alessandro , Bellastella Giuseppe , Visconti Daniela , Quinto Maria Chiara , De Bellis Annamaria , Mirone Vincenzo , Bellastella Antonio , Sinisi Antonio Agostino

The regulation of insulin-like factor 3 (INSL3) secretion from Leydig cells is still incompletely clarified. In this study we measured INSL3 serum levels in transsexual men under estrogen (E) and antiandrogen therapy or after orchiectomy. The effects of gonadotropins on testicular secretion in vitro was also evaluated.Methods: Blood samples were obtained from 14 transsexual men under long-term E (n=5) or E plus cyproterone acetate (E+CPA, <...

ea0011p682 | Reproduction | ECE2006

Effect of chronic tadalafil administration on penile hypoxia induced by cavernous neurotomy in the rat

Vignozzi L , Morelli A , Filippi S , Donati S , Luconi M , Zhang XH , Ambrosini S , Vannelli GB , Mirone V , Forti G , Maggi M

Objectives: Radical prostatectomy is an effective therapy for clinically localized prostate cancer. A significant number of men develops post-prostatectomy erectile dysfunction (PPED), due to surgery-related nervous damage. PPED is relatively refractory to PDE5i therapy. In a rat model of bilateral cavernous neurotomy we evaluated whether chronic tadalafil treatment (CTT) could ameliorate anatomical and functional damage to corpora cavernosa (CC).Methods...

ea0092op-10-03 | Oral Session 10: Novel diagnostics in Thyroid cancer | ETA2023

KI67 proliferative index, but not mitotic count and necrosis, is a prognostic factor in patients with medullary thyroid cancer: a single-center retrospective analysis according to the 2022 who pathological classification

Prinzi Antonio , Bosco Agata , Mirone Alessandro , Tumino Dario , Di Benedetto Guenda , Gambero Federica , Bartoloni Giovanni , Frasca Francesco , Belfiore Antonino , Malandrino Pasqualino

Background: The 2022 WHO Classification of Endocrine and Neuroendocrine Tumors has introduced, as other neuroendocrine neoplasms, new pathological features to classify medullary thyroid carcinoma (MTC) in low/high grade. However, whether it can be reliable in clinical practice should be confirm by further studies.Aim: To verify the predictive value of the 2022 WHO grading system in patients with MTC.Materials and Methods: Tumor tis...