Searchable abstracts of presentations at key conferences in endocrinology

ea0034pl5biog | SfE Transatlantic Medal Lecture | SFEBES2014

SfE Transatlantic Medal Lecture

Lazar Mitchell A

Mitchell A LazarDr Mitchell Lazar is the Sylvan Eisman Professor of Medicine and Genetics, the Chief of the Division of Endocrinology, Diabetes, and Metabolism, and the Director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania. He received his undergraduate degree in Chemistry from the Massachusetts Institute of Technology, then received a PhD in Neurosciences and an MD from Stanford University. He trained in Inter...

ea0078emm1.1 | Symposium 1 | BSPED2021

‘Fertility preservation in boys’

Mitchell Rod

Childhood cancer survival rates have increased dramatically over recent decades and currently >80% of children with cancer will survive over the long-term. This has resulted in a dramatic increase in the number of young adults experiencing late effects of treatment, including infertility. Ovarian tissue transplantation has recently proven successful for fertility restoration in girls. However, for prepubertal males due to receive gonadotoxic therapy there are currently no ...

ea0050cmw3.6 | Workshop 3: How do I. . . (1) | SFEBES2017

How do I . . . . implement patient safety alerts for adrenal insufficiency across my institution

Mitchell Anna

Steroid-dependent individuals, in particular those with primary adrenal insufficiency, are a vulnerable patient group. They are prone to acute adrenal crisis which is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency, acute adrenal crisis has a frequency of 6–8 per 100 patient-years. Unfortunately, delays in diagnosis and management are common, constituting an avoidable source of patien...

ea0050cmw3.6 | Workshop 3: How do I. . . (1) | SFEBES2017

How do I . . . . implement patient safety alerts for adrenal insufficiency across my institution

Mitchell Anna

Steroid-dependent individuals, in particular those with primary adrenal insufficiency, are a vulnerable patient group. They are prone to acute adrenal crisis which is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency, acute adrenal crisis has a frequency of 6–8 per 100 patient-years. Unfortunately, delays in diagnosis and management are common, constituting an avoidable source of patien...

ea0041s2.3 | Mixtures, medicines and diet, where now for endocrine disrupting compounds? (<emphasis role="italic">Endorsed by Endocrine Connections</emphasis>) | ECE2016

EDCs: assessing the risks of exposure to environmental chemicals and pharmaceuticals

Mitchell Rod

Many industrial chemicals and pharmaceutical products have been proposed to result in endocrine disruption in humans. This includes potential effects on reproductive development in males and females. Chemicals that have been proposed to impact on male reproductive development include plasticizers, synthetic oestrogens and analgesics. Much of the data on the effect of exposure to these agents are based on studies conducted in rodent models; however, confirmation of such finding...

ea0034pl5 | SfE Transatlantic Medal Lecture | SFEBES2014

Transcriptional coordination of circadian and metabolic physiology

Lazar Mitchell

Organismal metabolic homeostasis is normally accomplished by the physiological functions of several metabolic tissues, including liver, muscle, and fat. The endocrine system coordinates organismal metabolic homeostasis via hormones, such as insulin and glucocorticoids, that act on metabolic tissues to partition nutrients within a physiological range. Metabolic diseases, such as obesity and diabetes, ensue when these homeostatic systems fail. Normal metabolic physiology also di...

ea0078OC9.2 | Oral Communications 9 | BSPED2021

Sex steroid priming for growth hormone stimulation testing – a systematic review

Duncan Gregor , Mitchell Rod

Background: Growth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. Given that sex steroids impact on anterior pituitary function, there is concern around the efficacy of GH stimulation testing in pre/peripubertal children, where sex steroid levels are low. Sex steroid priming prior to GH stimulation testing is thought to improve test efficacy in these children, however evidence to support its use in clinical practice is limit...

ea0050ep106 | Thyroid | SFEBES2017

Hyperthyroidism secondary to weight loss supplements

Mitchell Kirsten , McDougall Claire

Case History: A 26 year old female patient was referred to her local endocrine clinic having presented to her GP complaining of ankle swelling. Routine biochemistry revealed a suppressed TSH (<0.05 U/l), and reduced serum levels of free T4 (2.0 pmol/l) and T3 (3.2 pmol/l). Random serum cortisol measurements were also elevated on 2 separate occasions (1266 nmol/l and 991 nmol/l). Clinical examination revealed her to be clinically euthyroid with no evidence of ...

ea0050ep106 | Thyroid | SFEBES2017

Hyperthyroidism secondary to weight loss supplements

Mitchell Kirsten , McDougall Claire

Case History: A 26 year old female patient was referred to her local endocrine clinic having presented to her GP complaining of ankle swelling. Routine biochemistry revealed a suppressed TSH (<0.05 U/l), and reduced serum levels of free T4 (2.0 pmol/l) and T3 (3.2 pmol/l). Random serum cortisol measurements were also elevated on 2 separate occasions (1266 nmol/l and 991 nmol/l). Clinical examination revealed her to be clinically euthyroid with no evidence of ...

ea0062wd5 | Workshop D: Disorders of the adrenal gland | EU2019

Lymphoma as a cause of bilateral adrenal gland enlargement and Adrenal insufficiency

Abdalaziz Altayeb , Mitchell Anna

: Lymphoma is one of the rare causes of bilateral adrenal gland enlargement that require a high index of suspicion for diagnosis. We present a case of 80-year-old lady referred by her GP for further evaluation after presenting with lower abdominal discomfort and weight loss for which she had a CT scan that revealed bilateral adrenal gland masses (60 HU) with the right adrenal gland measures 61 mm in diameter with distal ileal thickness and regional lymphadenopathy. She has no ...