Searchable abstracts of presentations at key conferences in endocrinology

ea0081p268 | Adrenal and Cardiovascular Endocrinology | ECE2022

Almost half of patients using inhaled corticosteroids have secondary adrenal insufficiency

Batheja Vishal , Mittal Neeru , Jagan Jacob Jubbin

Context: Secondary adrenal insufficiency (SAI) has been identified in over 22% of adults using inhaled corticosteroids (ICS).1 This has been co-related with the total daily dose and type of ICS along with individual genetic susceptibility among the subjects using ICS.1,2 Our recent paper suggested that 2.8% of adults with euvolaemic hyponatremia admitted to the hospital had ICS related SAI.3Objective: To determine prevale...

ea0025p23 | Bone | SFEBES2011

Ablation of AMP-activated protein kinase (AMPK) α1 catalytic subunit in mice leads to decreased bone loss after ovariectomy and impaired bone response to intermittent PTH treatment

Shah Mittal , Viollet Benoit , Korbonits Marta , Chenu Chantal

AMPK is a key regulator of cellular and body energy homeostasis. We previously demonstrated that AMPK activation in osteoblasts increases bone formation in vitro while deletion of the AMPKα1 subunit leads to decreased bone mass in vivo. To determine whether bone turnover can be stimulated in the absence of AMPKα1 subunit, we subjected WT and AMPKα1−/− mice to catabolic (ovariectomy: OVX) and anabolic (intermittent PTH adminis...

ea0009p138 | Steroids | BES2005

WNK kinases; a novel pathway regulating electrolyte balance and blood pressure, which is mutated in Pseudohypoaldosteronism type II

O'Reilly M , Marshall E , Mittal M , Kenyon C , Brown R

WNK1 and WNK4 are serine/threonine kinases, With-No-K (lysine) residue at a key catalytic position within the active site. Mutations in either cause Pseudohypoaldosteronism type II (Gordon syndrome), an autosomal dominant, hypertensive, hyperkalaemic disorder, especially responsive to thiazide diuretics (first line treatment for essential hypertension). This novel WNK pathway is implicated in normal regulation of blood pressure (BP) and distal nephron Na+/K+</s...

ea0006p20 | Cytokines | SFE2003

INVESTIGATION OF GROWTH HORMONE SECRETION AND SENSITIVITY IN RHEUMATOID ARTHRITIS

Mittal G , Marcora S , Lemmey A , Wayte A , Maddison P , Wilton A

Background: We have previously shown that systemic levels of the growth hormone (GH) dependent proteins IGF-I and IGFBP-3 are significantly lower in rheumatoid arthritis (RA) patients than in age and sex matched healthy controls.Aim: To investigate whether low levels of systemic IGF-I and IGFBP-3 levels in RA patients are due to GH deficiency or GH insensitivity.Methods: Eight RA patients (6 females, mean plus/minus SD, age 52.5 pl...

ea0021p22 | Bone | SFEBES2009

AMP-activated protein kinase (AMPK) regulates in vitro bone formation and bone mass in vivo

Shah Mittal , Bataveljic Attia , Violet Benoit , Arnett Tim , Saxon Leanne , Korbonits Marta , Chenu Chantal

Adenosine 5′-monophosphate-activated protein kinase (AMPK), a regulator of energy homeostasis, has a central role in mediating the appetite-modulating and metabolic effects of many hormones and neuromodulators. We previously demonstrated similar neuroendocrine activation of AMPK in bone-forming osteoblasts. In this study, we tested whether stimulation of AMPK activity in osteoblasts plays a role in their function and whether deletion of the catalytic AMPKα1 subunit,...

ea0011p397 | Diabetes, metabolism and cardiovascular | ECE2006

Dietary potassium driven responses in the renal WNK kinase pathway in vivo

O’Reilly M , Marshall E , MacGillvray T , Mittal M , Kenyon CJ , Brown RW

WNK1 (With-No-K, lysine) and WNK4 are serine/threonine kinases, mutated in Gordon syndrome (Pseudohypoaldosteronism Type II), a dominant, hypertensive, hyperkalaemic disorder; implicating this novel WNK pathway in normal regulation of blood pressure (BP) and electrolyte balance. Previous Xenopus oocyte work implicates WNK4 in regulation of K+ secretion via ROMK (renal outer medullary K+ channel) and Cl- transport pathways both paracellularly via tight junctions (claudin...

ea0008p35 | Diabetes, metabolism and cardiovascular | SFE2004

Instant 99mTc-ciprofloxacin scintigraphy for the diagnosis of Osteomyelitis in the Diabetic foot

Dutta PD , Bhansal A , Mittal BR , Singh B , Masoodi S , Reddy KSS , Ray P , Kumar V

AbstractThe diagnosis of osteomyelitis in diabetes mellitus remains a challenge. This study was conducted to evaluate the infection scintigraphy with instantly prepared single vial kit, radio-labelled ciprofloxacin (Diagnobact TM), as a mean to detect bone infection; in comparison with bacterial culture as gold standard. Written consent was taken from all patients including approval from institute ethics committee. Twenty-five patients with diabetic foot...

ea0057021 | Cardiovascular complications in pituitary gigantism (results of an international study) | BES2018

Cardiovascular complications in pituitary gigantism (results of an international study)

Liliya Rostomyan , Adrian Daly , Nalini Shah , Luciana A Naves , Anne Barlier , Marie-Lise Jaffrain-Rea , Philippe Emy , Sebastian Neggers , Lecumberri Santamaria Beatriz , Ian Holdaway , Thierry Brue , Gunter Stalla , Roberto Salvatori , Yves Bertherat Jerome , Dominique Maiter , Margaret Zacharin , Anurag Lila , Silvia Filipponi , Satinath Mukhopadhyay , Tapani Ebeling , Marja Ojaniemi , I McCormack Ann , Outi Kuismin , Anne-Lise Lecoq , Mona Sahnoun-Fathallah , Caroline Jung-Sievers , Elena Malchiodi , Liudmila Rozhinskaya , Elena Nazzari , Sachin Mittal , Elisa Verrua , Ekaterina Sorkina , Alexander Dreval , France Devuyst , Ismene Bilbao , Simona Auriemma Renata , Palacios Garcia Nuria , Irena Ilovaiskaya , Vyacheslav Pronin , Annamaria Colao , Diego Ferone , Anna Spada , Patrick Petrossians , Paolo Beck-Peccoz , A Stratakis Constantine , Philippe Chanson , Albert Beckers

Background: Cardiovascular disease is an important cause of morbidity/mortality in chronic GH hypersecretion.Aim: To evaluate cardiovascular system in a large series of patients with pituitary gigantism. Standard case report forms were used with height assessments related to local country norms. Results: 151pts (123 male) with GH-excess and abnormal growth velocity for age or final height >2SD over local norms had complete data on cardiac assessments...