Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep596 | Endocrine tumours and neoplasia | ECE2016

The role of insulin, IGFBP-3, folic acid, 25-OH-D, CA 19-9 and CA 72-4 as potential tumor’s predictors of the gastrointestinal tract in patients with acromegaly

Knyazeva Olga , Molitvoslovova Natalya , Rozhynskaya Lydmila

Introduction: Patients with acromegaly have increased risk of developing tumors of the gastrointestinal tract. There are some data that insulin, IGFBP-3, folic acid and 25-OH-D may influence the development of these tumors.Aim: To study the influence of insulin, IGFBP-3, folic acid and 25-OH-D, CA 19-9, CA 72-4 in the development of tumors of the gastrointestinal tract, and the frequency of neoplasms detection.Materials and Methods...

ea0037ep1171 | Clinical Cases–Pituitary/Adrenal | ECE2015

Three cases of successful pregnancy outcomes after different methods of therapy in women of acromegaly apart from remission of the disease

Molitvoslovova Natalia , Grigoriev Andrey , Trunin Yuri , Oleynik Olga

Reports of pregnancy in acromegalic women are uncommon.Case 1: Patient K., 25-year-old., 01/04/2008 – transsphenoidal adenomectomy in connection with active acromegaly (GH/OGTT – 47.2–64.0–38.0–29.6–28.7 ng/ml; macroadenoma 19×14×12 mm with compression of optic chiasm). Postoperative remission of the disease, recovery of menstrual function without additional therapy. At the end of August 2008 the patient became pre...

ea0035p717 | Neuroendocrinology | ECE2014

A rare incident of gastric mucinous adenocarcinoma in an acromegalic patient

Molitvoslovova Natalia , Oleynik Olga , Soldatova Tatyana , Leytes Yuriy

Acromegaly is frequently associated with tumor development of various organs, mostly with cancer of colon and thyroid gland while the development of gastric cancer is a very rare condition.We observed a 33-years-old woman with mild clinical signs of acromegaly. The diagnosis was confirmed by laboratory tests (increased levels of IGF1 and growth hormone – 573 ng/ml and 9.8 ng/ml respectively) and MRI (supra-infra-latero-cellary pituitary adenoma, 9&#...

ea0014p132 | (1) | ECE2007

Results of treatment of patients with pituitary somatotroph adenomas

Grigoriev Andrey , Molitvoslovova Natalye , Kolesnikova Galina , Kuzmin Anatolij

In ESC for the period since October 2004 till October 2006 were operated 69 patients with acromegaly. Men were 22 (32%), women – 47 (68%). Age of patients changed from 24 till 68 (middle – 47).All patients were separated into 2 groups: surgery (group 1) and combination treatment (group 2), which consist of surgery and somatostatin analogues therapy before and after surgery.In most cases were macroadenomas, only 5 patients...

ea0014p564 | (1) | ECE2007

Immunohistochemistry of pure growth hormone-containing and mixed growth hormone/prolactin-containing pituitary adenomas

Marova Evgeniya , Yushkov Petr , Molitvoslovova Natalja , Luljeva Elena

Transsphenoidal surgery is the most efficient primary treatment for acromegaly. However, some patients do not meet remission criteria after operation. Mixed growth hormone (GH)/prolactin (PRL)-secreting pituitary adenomas are known to predict poor surgical outcome. The aim of our study was to evaluate immunohistochemical markers in pure GH-and mixed GH/PRL-containing tumors and to investigate their prognostic value. In our study we included 39 acromegalic patients, who underwe...

ea0011p449 | Endocrine tumours and neoplasia | ECE2006

Surgical treatment in acromegaly: predictors of outcome

Iushkov PV , Molitvoslovova NN , Luljeva EG , Marova EI

Transsphenoidal surgery is the treatment of choice in acromegaly. However, some patients do not achieve postoperative remission. The aim of our study was to identify factors that predictive of a poor surgical outcome in patients with acromegaly. In our study we included 39 acromegalic patients, who underwent transsphenoidal surgery as initial treatment. We evaluated clinical, hormonal and radiological predictors based on magnetic resonance imaging (MRI). Also we examined immun...

ea0037ep664 | Pituitary: basic and neuroendocrinology | ECE2015

The status of blood antioxidant system in patients with active acromegaly

Faassen Maria , Pankratova Maria , Molitvoslovova Natalia , Peterkova Valentina , Baizhumanov Adil , Yusipovich Alexander , Kovalenko Svetlana , Maksimov Georgy

Introduction: The oxidative stress is supposed to be key factor in multiple diseases.The aim of the study was to examine the effects of excessive GH secretion on the blood antioxidant system: total antioxidant capacity (TAC) of plasma; superoxide dismutase (SOD) and catalase activities (CAT); ceruloplasmin (CP); non-protein thiol (NT), and level of thiobarbituric acid reactive substances (TBARS).Materials: Eleven patients with acti...

ea0029p780 | Endocrine tumours and neoplasia | ICEECE2012

The pilot study on clinical presentation of pituitary adenomas (Pa) in patients with multiple endocrine neoplasia type 1 (Men1) phenotype with and without Men1 mutation

Rostomyan L. , Tichomirowa M. , Kirdyankina N. , Mokrysheva N. , Molitvoslovova N. , Dzeranova L. , Tiulpakov A. , Rozhinskaya L. , Beckers A.

MEN1 germline mutations are identified in 70% of the familial forms of MEN1 and about 10%of the sporadic cases. Little is known about clinical differences between MEN1 with and without identification of MEN1 germline mutation particularly in terms of PA characteristics.Aim: To compare the clinical features of PA in MEN1 cases with and without germline MEN1 mutation and sporadic cases of PA. Patients and methods: Data were obtained in...

ea0026p204 | Pituitary | ECE2011

Efficacy of transsphenoidal surgery in treatment of Cushing’s disease: factors influencing postsurgical outcome

Molitvoslovova Natalia , Mamedova Elizaveta , Grigoryev Andrey , Kolesnikova Galina , Rozhinskaya Lyudmila , Arapova Svetlana , Marova Evgeniya

The study analyses direct postoperative and long-term results of surgical treatment of ACTH-secreting pituitary adenomas in 158 patients, operated between 2004 and 2009. There were 143 (91%) female and 15 (9%) male. The mean age of the patients was 36 years, S.D. 10.7. In all patients the diagnosis of Cushing’s disease was confirmed by high dose dexamethasone suppression test. Preoperative hormonal evaluation: ACTH (0800 h), pg/ml (Me-78.5 (50.5 (25th perce...

ea0016p465 | Neuroendocrinology | ECE2008

Gh/Igf-1 control and tumor growth reduction in active acromegalic patients on Octreotide LAR

Ilovayskaya Irena , Molitvoslovova Natalia , Egorova Olga , Dzeranova Larisa , Arapova Svetlana , Marova Evgenya

Prospective non-comparable randomized clinical investigation of GH/IGH-1 control and tumor growth reduction in active acromegalic patients on Octreotide-LAR is presented. Fifty patients (pts) with newly diagnosed acromegaly (primary teratment, group 1; mean age 47.8±13.9 years old) and 39 pts after previous surgical and/or radiological treatment (secondary treatment, group 2; mean age 48.1±12.2 years old) were treated with Ocrteotide LAR 20–40 mg every 4 weeks, ...