Endocrine Abstracts

Background: Several lines of evidence support the view that sarcopenia and osteoporosis are strictly connected. However, the capability of the updated sarcopenia definition to capture the concomitant presence of osteoporosis has been scarcely investigated. Aim: To assess the association between sarcopenia defined according to the revised criteria from the European Working Group on Sarcopenia in Older People (EWGSOP2) and osteoporosis in women with a frag...

Activation of the Ras/ERK pathway and stimulation of proliferation by integrins in thyroid cells requires CaMKII activation. To date, whether this role of CaMKII is a general mechanism or is restricted to integrin signalling is unknown. As oncogenic activation of the Ras/ERK pathway by mutated Ras, RET/PTC and Trk is frequent in papillary thyroid carcinoma (PTC), we investigated the expression and activation level of CaMKII in PTC primary culture and in stable cell lines.<...

Thyroid carcinoma arising from the thyroid follicular epithelium represents the most frequent endocrine malignancy and is mainly associated with gene rearrangements generating RET/PTC and TRK oncogenes, as well as BRAFV600E and RASV12 activating point mutations. Except for p53, which appears to be involved only in poorly differentiated and aggressive histotypes, a role of tumor-suppressor genes in the pathogenesis of thyroid cancer is still poorly known....

About 5–10% of fertile women have anti-thyroid antibodies (AAT); however this prevalence is higher in infertile women. Few studies have been focused so far on the role of thyroid autoimmunity in the outcome of ART. Aims of our studies have therefore been: a) evaluate prevalence of thyroid antibodies in infertile women before ART; b) investigate whether AAT are more prevalent in a specific subset of infertile women; c) investigate the possible influence of AAT or thyroid d...

Introduction: Natural history of lung neuroendocrine tumours (NETs) and in particular of two histological subtypes, atypical carcinoid (AC) and large cell neuroendocrine carcinoma (LCNEC), is poorly known.Aim of the study was to determine disease-free survival (DFS) and overall survival (OS) of sporadic, resectable, non-metastatic lung AC and LNEC.Patients and methods: This retrospective study involved 116 consecutive patients surg...