Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc10.5 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Splicing dysregulation is associated with aggresive and metabolic-associated liver disease-derived hepatocellular carcinoma

Sanchez Natalia Herman , Lopez-Canovas Juan L , del Rio-Morenos Mercedes , Amado Victor , de la Mata Manuel , Rodriguez-Peralvarez Manuel , Luque Raul M , Gahete Manuel D

Metabolic-associated fatty liver disease (MAFLD) is a growing cause of hepatocellular carcinoma (HCC), but the molecular mechanisms associated with the pathological progression from MAFLD to HCC are still to be fully elucidated. The genomic and transcriptomic profile of HCC samples have been widely described; however, the proteomic landscape of MAFLD-derived HCC samples is mostly unknown. Here, we sought to perform the first quantitative proteomic analysis of HCC samples from ...

ea0021s1.1 | Novel mechanistic insights into thyroid diseases | SFEBES2009

Human mutations causing hypothyroidism

Moreno Jose

Hypothyroidism is the most frequent innate endocrine disorder, reaching a prevalence of 1 in 1200 newborns. Defects causing hypothyroidism occur at any level of the hypothalamus-pituitary-thyroid axis, but also at peripheral tissues, where alterations of intracellular transport, deiodination or nuclear action of thyroid hormone have been described in humans.In recent decades, molecular research found evidence that hypothyroidism is a genetic disease. Def...

ea0020s14.2 | Thyroid | ECE2009

DUOX2 gene and thyroid disease

Moreno Jose C

Generation of hydrogen peroxide (H2O2) in thyroid cells is essential for the synthesis of thyroid hormone. H2O2 is produced by the Dual Oxidase 2 (DUOX2) at the apical membrane of the thyrocyte, where it is required by thyroperoxidase for the iodination of thyroglobulin. A dual oxidase maturation factor 2 (DUOXA2) was recently identified as an endoplasmic reticulum-resident protein required for expression of DUOX2 activity. DUOX2 and...

ea0081ep964 | Thyroid | ECE2022

Therapeutic approach to the diagnosis of Bethesda 5

Barrera-Martin Ana , Rosa Alhambra Exposito Mª , Moreno-Moreno Paloma , Angeles Galvez Moreno Maria

Introduction: Thyroid nodules are very common in the general population (20-75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 5.Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 5 (B5) in thyroid fine-needle aspiration cytology (FNA). And s...

ea0063p282 | Pituitary and Neuroendocrinology 1 | ECE2019

Cushing disease: Clinical presentation

Moreno-Moreno Paloma , Munoz-Jimenez Concepcion , Barrera-Martin Ana , Galvez-Moreno Maria Angeles

Objective: Cushing’s disease (CD) accounts for approximately 80% of cases of Cushing’s syndrome. Its clinic is nonspecific and its diagnosis difficult. The objective of this study is to review the most frequent clinical signs of this disease in our environment and compare it with that described in the literature.Patients and methods: Retrospective descriptive study of patients with CD. We included all patients diagnosed with CD (2005–2017)...

ea0063p287 | Pituitary and Neuroendocrinology 1 | ECE2019

Diagnostic tests in Cushing’s disease

Moreno-Moreno Paloma , Alcantara-Laguna Maria Dolores , Leon-Idougourram Soraya , Galvez-Moreno Maria Angeles

Objective: Cushing’s disease (CD) accounts for approximately 80% of cases of Cushing’s syndrome. Diagnosis of CD is difficult, it is carried out with a screening test and confirmation test. The aim of this study is to describe the diagnostic results of the different diagnostic tests used in the diagnosis of CD in our environment.Patients and methods: Retrospective descriptive study of patients with CD. We included all patients diagnosed with CD...

ea0049ep474 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Debut diabetes characteristics

Exposito Maria Rosa Alhambra , Sanchez Inmaculada Prior , Moreno Paloma Moreno , Moreno Maria Angeles Galvez

Background: The diabetes type 1 (DM1) is a chronic autoimmune disease, it tends to appear in childhood, its incidence continues to rise and the complications arising from improper care poses serious health problems for those who suffer. LADA diabetes is autoimmune diabetes which appear in adults.Objetive: To describe the characteristics of the new diabetes debut in our environment.Material and methods: We included all patients who ...

ea0049ep602 | Diabetes therapy | ECE2017

Real practice experience: Degludec vs Glargina U300

Exposito Maria Rosa Alhambra , Sanchez Inmaculada Prior , Moreno Paloma Moreno , Moreno M Angeles Galvez

Background: In last year, different analogues of very long duration basal insulin have appeared, which favors the flexibility in its use. Both ensure a decrease in the rate of hypoglycemia and improve glycemic control in clinical trials. However, in real practice we have few data in real practice.Objective: To compare the two ultralente insulin analogues in real practice. To analyze if they are cost effective.Material and methods: ...

ea0049ep1159 | Male Reproduction | ECE2017

Induction of male puberty in patients with hypogonadism hypogonadotrope with subcutaneous gonadotropin

Moreno-Moreno Paloma , Munoz-Jimenez Concepcion , Alhambra-Exposito Maria Rosa , Galvez-Moreno Maria Angeles

Objective: The most used therapeutic guidelines for the induction of male puberty in hypogonadotropic hypogonadism (HH) are GnRH in subcutaneous pulsatile infusion and HCG in monotherapy or combined with FSH in intramuscular injection. The objective of this study was to evaluate the efficacy of subcutaneous HCG with or without FSH in induction of male puberty in patients with HH.Patients and methods: Descriptive study of patients with HH treated with HCG...

ea0041ep753 | Neuroendocrinology | ECE2016

Prognostic factors of pituitary growth hormone-secreting tumors

Alhambra Exposito Maria Rosa , Ibanez Costa Alejandro , Moreno Paloma Moreno , Galvez Moreno Maria Angeles

Background: Acromegaly is the consequence of excessive growth hormone (GH) secretion, usually produced by a pituitary adenoma. Transphenoidal surgery is the first-choice treatment; however, the development of new drug therapies in the last years, specially the somatostatin analogues (SSA), has open new and promising avenues for the treatment of pituitary tumors.Objective: To determine whether a detailed knowledge of the clinico-pathological and radiologi...