Searchable abstracts of presentations at key conferences in endocrinology

ea0006p46 | Growth and development | SFE2003

The influence of birth weight on adipose tissue (AT) uncoupling protein 3 (UCP3) expression and thyroid regulation in neonatal pigs

Mostyn A , Litten J , Perkins K , Symonds M , Clarke L

Epidemiological studies have shown that infants of low birth weight show poor neonatal growth and increased susceptibility to adult diseases such as diabetes in later life. Pigs provide an ideal model to examine the influence of size at birth due to the natural variance in piglet weight within a litter. This study examined whether birth weight influences the expression of UCP3 and it's regulation by thyroid hormones in neonatal pigs.Piglets from 11 litte...

ea0008p57 | Growth and development | SFE2004

The influence of environmental temperature and hormonal manipulation on adipose tissue (AT) uncoupling protein (UCP) 3 expression in neonatal pigs

Elmes M , Litten JC , Perkins KS , Laws J , Symonds ME , Mostyn A , Clarke L

It is well established that the reduced neonatal mortality in Meishan, compared to commercial piglets, is due to resistance to hypothermia and hypoglycaemia. Underlying factors responsible for the differences in survival may include the disparity in plasma tri-iodothyronine (T3) concentrations and UCP expression (Mostyn et al (2004) Journal of Endocrinology, in press). ZD7114 (ZD), a synthetic beta3-adrenoceptor agonist, has been shown to improve thermogenesis in la...

ea0008p56 | Growth and development | SFE2004

The effect of thyroid hormone (T3) and a beta-adrenoceptor agonist on uncoupling protein 3 (UCP3) mRNA expression in porcine adipose tissue (AT)

Bos PM , Litten JC , Perkins KS , Laws J , Symonds ME , Mostyn A , Clarke L

There are many theories regarding the function of UCP3, including transportation of fatty acids out of the mitochondria and production of reactive oxygen species. The function of UCP3 may influence the development of obesity and diabetes mellitus. In rodents UCP3 mRNA levels increase after T(sub)3(/sub) treatment. The ancient Meishan breed has enhanced neonatal survival rates than lean commercial breeds (C). Previous studies have demonstrated that plasma T(sub)3(/sub) is lower...

ea0011s103 | Presenting your research – getting your work known | ECE2006

Practical tips for a perfect poster

Mostyn A , Budge H , Symonds ME

The key to a great poster is preparation – as soon as you receive notification of your poster presentation, read the ‘instructions for authors’. Key points to note are:The size of the poster boardsAttendance timesIs there a presentation in front of your poster?Turn-around time of the poster printer.The shape/size of the poster will be dictated by th...

ea0007p129 | Growth and development | BES2004

The effect of nutritional deprivation in late gestation on uncoupling protein-2 mRNA abundance in the ovine neonatal lung

Gnanalingham M , Mostyn A , Symonds M , Stephenson T

Uncoupling protein-2 (UCP2) has many postulated functions, including possible solute exchange and immunity within the neonatal lung. The effect of maternal nutrition during late gestation on UCP2 abundance in the ovine neonatal lung has not been determined.Twin-bearing ewes of similar age and body weight were individually housed from 110 days gestation. Six controls (C) were fed and consumed 100% of their energy requirements for maintenance and growth of...

ea0003s31 | Parturition and Fetal Stress - Hormonal Strategies for Ensuring Life After Birth | BES2002

Parturition and fetal stress: hormonal strategies for ensuring life after birth

Symonds M , Mostyn A , Budge H , Stephenson T

Fetal stress, including inadequate nutrient supply and cessation of fetal growth, are major stimuli to the onset of parturition which acts to promote maturation of the hypothalamic-pituitary axis. These adaptations, together with rapid removal of lung liquid fluid and onset of endogenous heat production at birth, ensure oxygen supply is adequate and hypothermia prevented. A critical component of fetal organ maturation in preparation for life after birth is mitochondrial develo...

ea0034p246 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Impact of chronic heart failure on adipose tissue functional plasticity: a role for fatty acids?

Yale Andrew , Cobb Malcolm , Lyon Alexander , Mostyn Alison

Chronic heart failure (HF) is a major cause of morbidity and mortality in humans and domestic animals. HF is characterised by chronic inflammation and functional changes in non-cardiovascular tissues; obesity is also associated with low level chronic inflammation, with adipose tissue (AT) exhibiting infiltration of macrophages and alterations in fatty acid (FA) profiles. The aim of this project was to investigate expression of regulators of lipid metabolism and inflammation an...

ea0025p206 | Growth and development | SFEBES2011

Effects of the prenatal environment on haematological and skeletal muscle parameters in one-week-old piglets: a role for glucocorticoids?

Fainberg Hernan , Almond Kayleigh , Bikker Paul , Symonds Michael , Mostyn Alison

Changes in maternal dietary intake during gestation can affect muscle development1 and may be linked to the catabolic actions of hormones, such as glucocorticoids, which inhibits the insulin like growth factor 1 (IGF1) pathway. This study examines the potential effects of glucocorticoids and skeletal muscle adaptations in seven-day-old offspring exposed to suboptimal gestational environments.Pregnant sows were randomly assigned to a commercial...

ea0019p292 | Reproduction | SFEBES2009

The influence of changes in macronutrient intake during gestation on gene expression of on glucocorticoid receptor (GR) and 11-beta-hydroxysteroid dehydrogenase 1 and 2 (11βhsd1 and 2) in the livers of neonatal pigs; effect of size at birth

Almond K , Lomax M , Bikker P , Symonds M , Mostyn A

Background: Altering maternal nutrition affects fetal development, potentially predisposing them to later metabolic disease. Tissue sensitivity to cortisol is regulated, in part, by GR and 11βhsd1 and 2, and GR and 11βhsd1 expression is known to be raised both with obesity and type 2 diabetes.Objectives: To examine whether gestational diet influences GR and11βhsd1 and 2 mRNA expression in the neonatal liver.Methods: ...

ea0004oc3 | Growth regulation and development | SFE2002

Influence of genotype on the endocrine and metabolic control of uncoupling protein (UCP)-2 during the first week of life in neonatal piglets

Mostyn A , Litten J , Perkins K , Symonds M , Clarke L

It is well established that neonatal mortality is greater in the leaner commercial (C) porcine genotypes compared to the ancient Meishan (M) breed, which has a higher percentage of body fat. Piglets do not express UCP1, responsible for heat production in neonatal mammals, although they do express UCP2. The aim of this study was to investigate the endocrine and metabolic control of UCP2 expression between the C and M genotypes.Piglets from 15 C and 15 M l...