Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp110 | Diabetes therapy & complications 2 | ECE2017

The method of reporting hypoglycemia in Randomized Control Trials (RCTs): a systematic review on RCTs conducted for SGLT-2 inhibitors

Kassir Noor , Medeiros Sarah , Farahani Pendar

Background: Hypoglycemia is an important side effect in pharmacotherapy of patients with diabetes mellitus. Medical organizations have tried to define hypoglycemia in clinical practice and RCTs with scientific statements and guidelines.Objective: To explore the method of reporting hypoglycemia conducted on SGLT-2 inhibitor RCTs.Methods: A systematic review using PubMed to find data on RCTs conducted for SGLT-2 inhibitors, limited t...

ea0035p105 | Calcium and Vitamin D metabolism | ECE2014

Brown tumor in a patient with ectopic mediastinal parathyroid adenoma: a case report

Qari Faiza , Nasser Tariq

Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism.Case: A 55-year-old Saudi woman was admitted to King Abdulaziz University Hospital (Jeddah) with a complaint of anterior maxilla mass of one month duration. Her medical history was unremarkable.Initial examination revealed a painful mass in the anter...

ea0032p715 | Neuroendocrinology | ECE2013

RET codon 618 mutation is the most frequent genotype in saudi families with multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma

Qari Faiza , Nasser Tariq

Background and objectives: Certain diseases, such as multiple endocrine neoplasia type 2A (MEN2A), MEN2B, familial and sporadic medullary thyroid carcinoma (MTC) and renal dysgenesis are related to abnormalities of the RET protein. Our aim was to evaluate the frequency of RET mutation in ten Saudi families with MEN2A and familial medullary thyroid carcinoma.Design and setting: Cross-sectional prospective study of patients followed up at King Abd...

ea0032p716 | Neuroendocrinology | ECE2013

Neurological manifestations of Vitamin D deficiency, is there any significant clinical correlation?

Qari Faiza , Nasser Tariq

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of Vitamin D deficiency and the levels of 25(OH) D and bone profile.Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2010 and December 2011. We collected information on demographic data, etiological factors for Vitamin D deficiency, clinical pr...

ea0029p126 | Adrenal medulla | ICEECE2012

A case of adrenoleukodystrophy presenting as progressive cerebellar dysfunction

Qari F. , Nasser T.

Previously asymptomatic 29-year-old Saudi male patient, presented to with a history of dizziness, abdominal pain and diarrhea for three days.His morning 800 h serum cortisol was 6.4 μg/dl (normal: 5–25 μg/dl); plasma ACTH was 7579 pg/ml (normal: <46.00). The diagnosis of acute adrenal crisis was made which confirmed later by a defective rise in the cortisol level with ACTH stimulation test.The patient was admitte...

ea0022p746 | Thyroid | ECE2010

Pheochromocytoma, papillary thyroid carcinoma: new entity

Nasser Tariq , Qari Faiza

A 53 year-old woman presented with labile and difficult to control hypertension on three deferent anti hypertensive medications. Abdominal computed tomography (CT) and Ultrasonography of the thyroid gland showed 1.8 cm thyroid nodule. Fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. Serum TSH & FT4, calcitonin, CEA, intact PTH and calcium levels were within normal limits. A 24-h urine metanephrines showed significant elev...

ea0090p522 | Thyroid | ECE2023

Cardiovascular health status among thyroid cancer survivors

Kaouache Nadjib , Nouri Nassim

Background: Thyroid cancer have good global prognosis with survival rate exceeding 85% at 5 years. Survivors are exposed to higher cardiovascular morbidity and mortality than the general population. The objective of this study is to quantify the prevalence of cardiovascular health levels in an Algerian cohort of thyroid cancer survivors who were considered free of any classical cardiovascular risk factors or cardiovascular diseaseMethods: A cohort of pat...

ea0026p365 | Adrenal medulla | ECE2011

Pheochromocytoma occurs in Saudi patients with MEN 2A

Nasser Tariq , Karawagh Abdullah , Qari Faiza

Objective: To evaluate pheochromocytoma that occurs in Saudi patients with MEN 2APatients and methods: Of 44 patients belonging to 5 MEN 2A families, 14 (31.8%) presented with pheochromocytoma. The following variables have been studied: clinical and diagnostic data (age, mutation, clinical features, and laboratory studies included measurements of 24-h urinary catecholamines, epinephrine, metanephrine, norepinephrine, dopamine, vanillylmandelic acid, and ...

ea0022p797 | Thyroid | ECE2010

Reversible thyrotoxic cardiomyopathy

Nasser Tariq , Kjnsarah Abdulhalim , Karawgh Abdullah

A 47-year-old, previously healthy, ex-smoker male presented with a two-week history of dyspnea grade 4 with progressive course, palpitations, orthopnea, and paroxysmal nocturnal dyspnea. There was no history of chest pain or fever, but he had noticed recent an unintentional 10 to 15 kg weight loss over the previous 3 months. There was no previous history of cardiorespiratory problems, hypertension, and diabetes. On examination he was dyspenic, anxious and tremulous. His temper...

ea0021p126 | Cytokines and growth factors | SFEBES2009

Differential effects of eicosapentaenoic acid (EPA) and palmitate on tumour necrosis factor (TNF-α) and insulin-like growth factor (IGF1) action in murine skeletal muscle cells

Saini Amarjit , Al-Shanti Nasser , Stewart Claire

Introduction: Sarcopenic obesity prevails with ageing, encompassing excess weight gains and muscle mass or strength losses. Free fatty acids and proinflammatory cytokines are elevated in obese adults. Palmitate decreases the anabolic effects of IGF signalling, while EPA elicits anti-inflammatory activities.We aimed to examine the effects of palmitate and EPA on TNF-α/IGF1 interactions in established models of skeletal muscle cell loss.<p class="...