Endocrine Abstracts

Some studies reports the high prevalence of unsuspected hypercortisolism in high-risk populations.Aim: To evaluate the prevalence of undiagnosed hypercortisolism in patients with diabetes mellitus (DM), adrenal incidentaloma and obesity.Material and methods: We prospectively evaluated 30 DM patients (8 male, 22 female, 53.5 years old (18; 73), HbA1c-7.1% (5.6; 13.8)), 22 patients with adrenal incidentaloma (6 male, 16 female, 53.5 ...

In 24 years old woman in March 2007 was diagnosed acromegaly (somatoprolactinoma) an active phase, hyperprolactinemia. Manifestations: rugged features, amenorrhea, galactorrhea, fasting GH – 144 ng/ml (N<10 ng/ml), IGF-1 – 586 ng/ml (N 48–450 ng/ml), PRL – 6726 mU/l (N 40–530 mU/l). According to pituitary MRT a tumor volume was 14.4 cm3, with supra- and infrasella growth. She was operated in May 2007: transnal transs...

Aim: To estimate efficiency of 200 mkg/day iodine for prevention of development of hypothyroxinemia in pregnant women with non toxic goiter and without it, who were living in region with mild iodine – deficiency.Subjects and methods: Study group consists of 32 pregnant women: 16 – with non toxic goiter (8 from them took 200 mkg of iodine), 16 - without thyroid disease (8 from them took 200 mkg of iodine).Results: Pregnant...

Background: Dulaglutide has been approved as a hypoglycemic agent for the treatment of patients with T2DM. A positive effect on carbohydrate metabolism and body weight was shown in RCT.It was found that GLP-1 agonists may prevent the progression of NAFLD directly affecting lipid metabolism and inflammation.Aim: To assess the effect of dulaglutide on carbohydrate and hepatic metabolism in patients with T2DM and NAFLD in real clinica...

The aim of the study is to compare efficacy of RAI in patients with Graves disease using different methods calculation of optimum therapeutic activity.Methods: About 60 patients (50 women, 10 men, mean age 44.8±11.8 years) with Graves decease were treated with RAI. The treatment with ATD was cancel 10 days before RAI to restore the iodine intake by thyroid gland. Therapeutic activity was determent individually 1) with applied the special formula in ...

The aim of the study is to estimate the efficacy of intravenous corticosteroid therapy in patients with active, sever Graves’ ophthalmopathy.Material and methods: 16 patients with bilateral active, sever Graves’ ophthalmopathy were included to the study. Euthyroididsm has been provided, mean dose of methimasol therapy was 9.4±6.6 mg a day, median of TSH- 0.3 mlU/l, median of fT4 –15.3 pmol/l. The median of duration of GO was 6.5 month...

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

Aim: To evaluate the effectiveness of the Bethesda system for reporting thyroid cytopathology in the prediction of thyroid cancer on fine needle aspiration (FNA).Materials and methods: This is retrospective study of 70 detected thyroid cancer. Thyroid ultrasound and FNA were performed on all patients. 66 of them with cancer suspicion were communicated to the thyroid surgeon, 4 cases of papillary carcinoma were accidentally diagnosed after hystological in...

Objective: To evaluate the frequency of symptoms of Cushing’s disease (CD) at baseline and it dependence on different quantities.Material and methods: Clinical and laboratory data of 44 patients with CD (40 females and four males, 37.9±10.5 years old), duration of the disease 35.5 (22; 75) months.Results: Complaints: i) >80% – fatigability, weight gain, apathy, and headache, ii) 40–50% – loss of libido,...

Aim: To estimate the frequency of changes in thyroid function on the background of antiviral therapy in patients with chronic hepatitis C.Material and methods: The retrospective group was consists of 204 patients (mean age 35.5±8.4 years) with HCV genotype 3a, who took the antiviral therapy course with pegylated interferon and ribavirin during 24 weeks. The patients were divided for two groups: 86.3% (176) had a sustained virological response (SVR),...