Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep33 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pediatric retroperitoneal paraganglioma with uncommon symptom treated successfully by laparoscopic surgery: Case report and literature review.

Khoa Dieu Van Nguyen , Dinh Duc Nguyen , Nguyen Linh , Quang Bay Nguyen

Introduction: Pheochromocytoma and paraganglioma are rare in the pediatric population occurring in approximately 1 in 50 000 children. The clinical presentation may range from asymptomatic to the classic triad of episodic diaphoresis, headache, and palpitations. Among hypertensive children, the incidence of surgically confirmed pheochromocytoma or catecholamine-secreting paraganglioma ranges from 0.8 to 1.7 percent. Catecholamine-secreting paragangliomas are often loc...

ea0092ps2-12-02 | Nodules 1 | ETA2023

Efficacy and safety of single-session radiofrequency ablation in treating benign thyroid nodules: A short-term prospective study

Nguyen Van Bang , Nguyen Thi Xuan , Nguyen Van Vy Hau , Nguyen Hai Thuy , Nguyen Dinh Toan , Van Le Chi

Objective: The aims of this study are to evaluate the safety and efficacy of RFA in the treatment of benign thyroid nodule(s) and to find independent factors related to the volume reduction rate of the nodule(s).Materials and methods: This short-term prospective study from a single medical center was conducted on 93 benign thyroid nodules in 93 patients treated with RFA. Two basic techniques were used: the trans-isthmic approach, moving-shot technique. C...

ea0092ps2-12-01 | Nodules 1 | ETA2023

Radiofrequency vesus ethanol ablation for single-session treatment of benign cystic thyroid nodules: a short-term retrospective study

Nguyen Van Bang , Nguyen Thi Xuan , Nguyen Van Vy Hau , Nguyen Tuyen Linh Pham , Nguyen Hai Thuy , Dinh Toan Nguyen , Van Le Chi

Objective: This study aims to compare 1-monthÂ’s efficacy and safety of single-session ethanol ablation and radiofrequency ablation for treating both purely cystic nodules and predominantly cystic thyroid nodulesMaterials and Methods: This short-term retrospective study was approved by the Ethics Committee of the Institutional Review Board of Danang Family hospital, and written informed consent for procedures was obtained for all patients. 39 patient...

ea0064016 | Is it worthwhile to distinguish between grade 1 and grade 2 subclinical hyperthyroidism for alteration of metabolic parameters? | BES2019

Is it worthwhile to distinguish between grade 1 and grade 2 subclinical hyperthyroidism for alteration of metabolic parameters?

Nguyen T , Russo L , Kyrilli A , Moreno-Reyes R , Corvilain B

Aim of the work: The effects of subclinical hyperthyroidism (SCH) on bone and heart have been well documented. Effects on other parameters like lipids metabolism and weight regulation have also been reported but mainly in cross-sectional studies. The potential benefits of treatment of endogenous subclinical hyperthyroidism are more controversial as few large controlled studies on clinical outcomes have been performed. ATA guidelines recommend treatment according to the severit...

ea0063p439 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Imaging studies of a parathyroid carcinoma case

Nguyen Thi Ngoc Huyen , Mathey Celine , Sitoris Georgiana , Kleynen Pierre

Parathyroid carcinoma is a rare neuroendocrine tumor, responsible for less than 1% of all cases of primary hyperparathyroidism. The sole curative treatment is complete surgical removal and thus, an accurate preoperative diagnosis is necessary. Due to the rarity of this disease, there is no staging guidelines. Imaging of parathyroid glands is usually obtained with ultrasonography, computed tomography, scintigraphy and positron emission tomography. These imaging modalities have ...

ea0013p195 | Diabetes, metabolism and cardiovascular | SFEBES2007

Apoprotein B and the likelihood of myocardial infarction among persons with reduced kidney function in the U.S. population: the third national health and nutrition examination survey (NHANES III)

O’Shea LA , Nguyen HT , Murthy BVR , Stack AG

Apolipoprotein (Apo)-B is a strong predictor of coronary risk in the general population. Whether it contributes to coronary disease in patients with reduced kidney function is unclear. We examined the prevalence and relationship of Apo-B with physician-diagnosed myocardial infarction among 7,404 adults age >20 years with reduced glomerular filtration rate (GFR) in the U.S. population. GFR was estimated Modification of Diet in Renal Disease Study (MDRD) equation and calibra...

ea0009p155 | Thyroid | BES2005

Expression of connective tissue growth factor in human thyroid tissue

Nguyen Q , Buchanan M , Watkinson J , Eggo M

Connective tissue growth factor (CTGF aka CCN2), is known to be up-regulated by transforming growth factor beta (TGF beta) and plays important roles in cell cycle control, growth, differentiation, cell adhesion, migration, angiogenesis and ECM production. CTGF is overexpressed in fibrotic disease e.g in kidney, lung, heart as well as in tumours. We have examined expression of CTGF in thyroid tissue because TGF beta is known be an autocrine factor, regulated by iodide. Immunohi...

ea0063p48 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Pharmacokinetic Interaction Study of the Effects of Multiple-dose Gastric Acid Reducers Omeprazole (OMP) and Famotidine (FAM on the Pharmacokinetics (PK) of Single-dose Telotristat Etiprate (TE) in Healthy Subjects

Wilson Alan , Qubeck Christine , Warner Chris , Tesfaye Eshetu , Nguyen Quyen , Wason Suman

Background: TE is indicated for the treatment of carcinoid syndrome diarrhea in patients with metastatic neuroendocrine tumors.Objective: To evaluate the effects of a proton pump inhibitor (OMP) and H2 antagonist (FAM) on the PK of TE and its active metabolite LP-778902 via an open-label study of OMP (40 mg orally QD × 4 days) or FAM (40 mg orally BID × 4 days) with a single 250 mg oral dose of TE. Eligible subjects: healthy, nonsmoking, aged &...

ea0041gp57 | Cardiovascular endocrinology | ECE2016

Prioritizing drug targets for non-alcoholic fatty liver disease based on comorbidity network analysis

Nguyen Thanh-Phuong , Sauter Thomas , Caberlotto Laura , Lammert Frank , Schneider Jochen G

Background and aims: Non alcoholic fatty liver disease (NAFLD) is highly associated with other components of the metabolic syndrome, in particular obesity and diabetes. However, systematic network medicine approach of the complex phenotypic dependencies and comorbidities has yet to be performed. Our aim now is to identify novel drug targets for NAFLD treatment by a systematic in silico network analysis.Methods: We constructed an interaction network of cu...

ea0038p200 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

AMPK activators modulate pro-inflammatory responses in human adipocytes

White Anna , Mancini Sarah , Nguyen Dinh Cat Aurelie , Montezano Augusto , Salt Ian , Touyz Rhian

Adipose tissue inflammation may be an important mechanism in the development of systemic insulin resistance, such that modulation of this system may be a therapeutic target for type 2 diabetes and obesity-related disorders. AMPK has anti-inflammatory properties, yet the anti-inflammatory actions of AMPK in adipocytes remain poorly characterised. We questioned whether AMPK activation influences pro-inflammatory responses in cultured adipocytes in basal and stimulated conditions...