Endocrine Abstracts

Background: Leading position among endocrine pathology of adolescence and young women is type 1 diabetes (T1D), which in recent years had been proved to have a strong association with reproductive dysfunction among such patients. The purpose was to investigate the features of reproductive health in 120 young women (18–22 years old) with T1D.Methods: Retrospectively we studied the features of puberty and prospectively examined level of blood glucose ...

Background: Aromatase inhibitors have been introduced as a new treatment modality in controlled ovarian stimulation as they were found to elevate follicular sensitivity to gonadotropins.The purpose of this study was to evaluate whether IVF outcomes will differ between poor responder patients who receive high doses of gonadotropins alone or low doses of gonadotropins with letrozole during ovulation stimulation.Methods: Patients who ...

Background Comprehensive evaluation of the effect of surgery in patients with primary hyperparathyroidism (PHPT) and monitoring of patient’s well-being after treatment including assessment of patient-reported outcomes is worthwhile.AIMWe aimed to assess changes in quality of life (QoL) and symptoms in patients with symptomatic and asymptomatic PHPT after surgery (parathyroidectomy, PTX).Materials and methods.Adult patients wit...

Objective: Metformin is one of the most widely used drugs in primary therapy for the treatment of type 2 diabetes (T2D). Despite its overall efficiency in T2D treatment metformin shows significant proportion of patients suffering from number of side effects. So far number of polymorphisms mainly in genes coding for various metformin transporter proteins have been described in association with metformin efficiency. However, no information exists on influence of genetic variatio...

Association studies between genetic variants of adiponectin gene and susceptibility to type 2 diabetes (T2D) and increased body mass index (BMI) have provided contradictory results. We selected 10 SNPs (rs2241767, rs1501299, rs3777261, rs16861210, rs2241766, rs822396, rs182052, rs17300539, rs16861194, rs266729) in promoter and coding regions of adiponectin gene based on haploblock structure and previously reported association studies. Selected SNPs were screened in 170 patient...

Full gene coding sequence of somatostatin receptor 5 and 2000 bp of upstream region was estimated using direct sequencing in 28 patients with acromegaly and 97 controls. Total 19 polymorphisms were identified (SNP1-19) and possible haplotypes were reconstructed. From all polymorphisms found silent substitution SNP15 was significantly associated with acromegaly as compared with control group (P=0.005). Another substitution SNP17 involves the amino acid change from prolin...

Primary hyperparathyroidism (PHPT) is a complex endoctinopathy that involves parathyroid glands which secreting too much parathyroid hormone and due to causes hypercalcemia effecting different organs and leading to significant quality of life (QoL) impairment. QoL assessment before and after surgery in patients with PHTP may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient’ condition after surgery, including in real ...

Background: Many patients with type 2 diabetes (T2D) are not reaching glycemic targets even by using different combinations of antidiabetic drugs, including insulin. On the other hand, intensified multidrug therapy is associated with increased risk of severe side effects and individualized selection of medication is essential. The aim of our study is to evaluate efficiency of personalized pharmacotherapy according to the genotype and phenotype of T2D patients.<p class="abs...

Background: A parathyroidectomy (PTX) is the preferred standard treatment for patients with primary hyperparathyroidism (PHPT). the assessment of the surgery success from patient’s perspective is important to provide patient-centered care.Aim: We aimed to evaluate QoL changes in PHPT patients during 2-years follow-up after PTX and to identify preoperative predictors of meaningful QoL improvement after surgery.Materials and Met...