Endocrine Abstracts

Apoptosis plays a pivotal role in the regulation of the immune mechanisms in the pathogenesis of autoimmune thyroid diseases. The aim of the study was to compare soluble Fas, FasL and Bcl-2 in Graves’ disease (GD) and Hashimoto thyroiditis (HT) in relation to the age of the studied patients. The study was carried out in 5 groups of subjects: 1/14 patients with GD in euthyreosis on methimazol (euGD) 2/20 patients with hyperthyroid GD (hrGD) 3/15 patients with HT in euthyre...

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...