Endocrine Abstracts

With the wide-spread use of abiraterone/enzalutamide for CRPC, there is an urgent need to understand and reverse resistance to these treatments. Studies have implicated glucocorticoid receptor (GR) as activating androgen receptor (AR) signalling and driving resistance. Here we studied progesterone receptor (PR), which is phylogenetically most closely related to the AR. We first used digital droplet PCR in prostate cancer (PCa) cell lines and observed >10 times higher level...

Long-acting somatostatin analogs are now increasingly being prescribed as adjuvant and primary therapy for the treatment of acromegaly. Many studies have shown them to be both effective and safe, by suppressing GH levels and normalizing serum IGF-1 levels in most cases.The aim of the study was to analyze the case report of a female patient with active acromegaly and evaluate the efficacy of long-acting synthetic analog of somatostatin (Sandostatin LAR) for biochemical control ...

The current PDA recommendations relating to the good metabolic control of diabetes are: self-controlled fasting blood glucose (FBG)70–90 mg%, HbA1c ≤6.1%, lipid profile (LP) TChol ≤175 mg%, LDL≤100 mg%, HDL ≥40 mg%, TG≤150 mg%.Objective: To evaluate the accomplishment of the proper metabolic control in diabetic outpatients with regard to the PDA guidelines.Material and Methods: a548 diabetics (249...

Introduction: Insulinomas are usually singular adenomas <1 cm. Less than 5% have diameter >3 cm. Multiple adenomas frequency is estimated on 3 do 9%. Malignant insulinomas are diagnosed in 3–6% patients. The oldest patient with insulinoma described in literature was 95 years old. About 30–50% of patients are previously misdiagnosed.Aim of the study: The aim of the study was presentation of patients with rare clinical characteristics of ...

Introduction: Hypopituitary patients receiving conventional hormone substitution, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.Aim of the study: The aim ...

Objective: The aim of the study was to evaluate distribution of circulating adiponectin (AdipoQ) isoforms at pregnant women with gestational diabetes mellitus (GDM) and comparison analysis of isoform distribution changes 12 months after delivery.Design: The study was conducted on 64 pregnant women who underwent routine pre-natal tests for GDM between 24 and 28 week of gestation and 30 of them 12 months after delivery. The study group included 36 women di...

Introduction: Hypopituitary patients receiving conventional hormone replacement, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.The aim of the study is an ...

The silent myocardial ischemia is a serious diagnostic problem especially in patients with long-standing diabetes of type 1 (DM). Resting as well as exercise myocardial perfusion scintigraphy tests allow to recognize the silent myocardial ischemia in these groups of patients and to start the relevant treatment. The aim of the study was to establish the prevalence of myocardial ischemia in patients with type 1 DM, without clinical symptoms of ischemic heart disease (IHD) and wi...

Cognitive dysfunctions, observed in the course of thyroid diseases (hyper- and hypothyroidism), have – in the recent years – been the subject of interest for many research teams. Even mild disorders of thyroid functionality are associated with hormone concentration changes which affect the general mood and cognitive functions. The efficiency of cognitive functions, which allow the man’s adaptation to environment al conditions, is determined by the activities of ...

Objective: Previous studies indicated that two glucocorticoid receptor gene polimorphisms bclI and N363S (GC-S) are associated with increased sensitivity to glucocorticoids and two other polymorphisms 9β and ER22/23EK (GC-I) are related to decreased sensitivity to glucocorticoids. The aim of the study was to determine whether these genetic changes can effect on the occurence of steroid-induced adverse events.Methods: One hundred and fifty p...