Endocrine Abstracts

Adrenal incidentalomas (AIs) are tumours accidentally detected by various imaging methods applied without suspecting adrenal pathology, indicating that most of them are nonfunctional. The most frequent hormonal alteration in AIs is autonomous cortisol secretion (ACS), a condition of altered hypothalamic-pituitary-adrenal axis activity, established on the biochemical parameters of hypercortisolism, without phenotype expression of Cushing’s syndrome. Since mild hypercortiso...

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...

Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of glucocerebrosidase with consequent massive acumulation of lipid-laden macrophages in various tissues. Estimated life expectancy is about 9 years shorter than for the reference population. Mortality due to macrovascular diseases is higher, and probably associated with metabolic abnormalities found in GD type 1 patients, including decreases in serum adiponectin levels. Because adip...

Introduction: Several population-based studies have shown that hyperinsulinemia and insulin resistance could be an independent predictive factor for development of coronary artery disease (CAD).Aim: The aim of this cross-sectional study was to analyze insulin secretion in patients with proven coronary artery disease.Methods: We have analyzed 151 consecutive patients (35–79 years old, men 68%, women 32%) referred for coronary a...

Introduction and aim: Obesity epidemic contributes to the increasing prevalence of high blood sugar, high blood pressure, and dyslipidemia, which are all known risk factors for coronary artery disease (CAD). Metabolic syndrome (MS) describes the common clinical finding wherein component CAD risk factors cluster within a single patient. Since obesity shares common clinical characteristics with both metabolic syndrome (MS) and Cushing’s syndrome it is speculated about obeso...

Somatostatinomas are rare neuroendocrine tumors of the pancreas and small intestine that can occur sporadically or in a syndromic form. Duodenal somatostatinomas are often associated with neurofibromatosis type1 (NF1). Their presenting features are mostly related to local effects of the tumor mass rather than functional clinical syndrome. Nesidioblastosis is extremely rare cause of persistant hyperinsulinemic hypoglycaemia in adults.We present a case of ...

A 25-year-old female, referred because of left hemianopsy, weight gain, fatigue, muscle weakness, and secondary amenorrhea. Physical examination revealed overt Cushingoid features and left temporal hemianopsy. Previously the diagnosis of pituitary macroadenoma (MRI) with suprasellar, infrasellar, and right parasellar propagation was made in regional hospital. Laboratory results showed moderate hypercalcemia with hypophosphatemia and hypercalciuria with inappropriately normal P...

Objectives: Besides well known increased adrenal androgen production, an enhanced peripheral cortisol metabolism was also observed in polycystic ovary syndrome (PCOS). This could induce a compensatory rise of ACTH secretion, tending to maintain normal plasma cortisol concentration at the expense of adrenal androgen excess. On the other hand, obesity is associated with a hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis and impaired androgen balance. In t...