Endocrine Abstracts

Introduction: Non-functioning pituitary tumors and primary empty sella are a common pathology within the differential diagnosis of pituitary masses. The manifestations will depend on the size of the tumor and the compression of adjacent structures being the most frequent neurological symptoms. Clinically the two entities are very similar and no clinical tools are known to be able to help the differential diagnosis.Objective: Perform a clinical and compar...

Objectives: Hypophosphatasia (HPP) is a rare genetic disorder. Early diagnosis is challenging due to the disease’s complexity and low physician awareness.1 This study aimed to demonstrate how a digital health approach that scans electronic health records (EHR) may lead to earlier diagnosis of HPP.Methods: Patients with HPP were identified in the Optimum Patient Care Research Database (OPCRD), a UK database of 13.7 m...

Introduction: Prolactin-producing pituitary adenomas are the most common pituitary tumors in clinical practice. In men they are more aggressive and their response to pharmacological treatment is unknown.Objective: Describe the clinical characteristics and response according to the treatment of a group of male patients with invasive macroprolactinomas.Materials and methods: A retrospective descriptive study, a series of cases, in 30...

Introduction: Among various comorbidities of human immunodeficiency virus-1 (HIV-1) infection, male hypogonadism is very frequent with a prevalence of 19% in patients treated with highly active anti-retroviral therapy. However, literature data are still lacking and achieved by studies with <300 subjects each.Aim of the study: Prevalence and clinical characterization of hypogonadism among a large number of men with HIV-1.Methods...

Introduction: HIV-infected patients often display a moderate to severe GH deficiency (GHD). To investigate the effects of r-hGH on hormonal parameters and body composition in patients with HIV-related lipodystrophy (HIV-r-L) and concomitant GHD, we studied 60 patients with HIV-r-L, 28 male and 32 females aged 18–65 years. According to their response to GHRH+Arginine (GH peak assumed to be normal when >7.5 ng/ml) patients were assigned to the following 3 groups: Group ...

Introduction: Rituximab is indicated in patients with active rheumatoid arthritis (RA), which through the Fab domain, binds to the CD20 antigen on the surface of B lymphocytes, generating lysis of B cells, present in the thyroid, by cytotoxicity dependent on complement, as a result of the binding of C1q, mediated by the Fc domain, destroying the thyroid follicles, by infiltration of inflammatory cells (1) (2).Objective: Describe the characteristics of pa...

Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due exposure to asbestos. Of note, different growth factors and their receptors are involved in the pathogenesis of MPM and resistance to therapy. Chemotherapy with cisplatin (cis) and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), besides stimulating GH secretion in the ant...

Introduction: Familial neurohypophyseal diabetes insipidus (FNDI) is a rare form of central diabetes insipidus (CDI) characterized by childhood-onset progressive polydipsia and polyuria due to mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene.Case description: Two male siblings were referred at 1 month of age to exclude CDI owing to a family history of CDI in the father and paternal grandfather. The proband was the fa...

Background: The penis has been compared to a barometer of endothelial health, being erectile dysfunction (ED) an early sign of endothelial dysfunction. The aim of the study was to investigate the association between ED and endothelial dysfunction in patients with HIV infection on ART.Methods: In this observational cross-sectional study we evaluated the prevalence and factors associated with ED in a cohort of 133 HIV-infected men. Evaluation tools include...

Introduction: Male hypogonadism is very frequent in men treated with highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus-1 (HIV-1) infection, reaching a prevalence of about 20%. Literature data regarding the time course of serum total testosterone (T) levels in these patients are lacking.Aim of the study: To evaluate changes of T levels over time in HIV-positive men with an initial finding of low T (<300 ng/dl).<p class...