Endocrine Abstracts

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Mrs SP was a 50-year old patient who presented with typical features of Cushing’s syndrome in 2003 and proceeded to pituitary surgery. Following this she was not cured, and elected to have a bilateral adrenalectomy. Following this, she was initially commenced on hydrocortisone 30 mg daily taken as 15 mg in the morning, 10 mg at noon and 5 mg at 1600 h, and fludrocortisone 100 μg daily. She continued on this for 10 years, but switched her glucocorticoid replacement to...

Background and aims: Diabetic neuropathy is a common complication in patients with type 1 diabetes mellitus (T1D). In this study, we explore the importance of circulating chemokines for the development of diabetic neuropathy (DN) in T1D.Materials and methods: This study was a cross-sectional analysis of patients with childhood onset T1D followed prospectively in a long-term longitudinal cohort study. Fifty-two patients (20 women/32 men; mean age 28 &#177...

Presence of primary hyperparathyroidism (PHPT) in patients with thyroid disease has been previously reported. However, co-existence of PTHPT and papillary thyroid cancer (PTC) has been reported very rarely, mainly in the form of isolated case reports. Since the pathophysiological mechanisms of the two diseases are theoretically quite different, no causal relation between these diseases has been inferred. The aim of this study was to investigate the presence of PHTP in individu...

We here report the cases of two patients receiving glucocorticoid replacement, whose treatment has been guided by serum prednisolone measurements and whose day curves are presented below. Ms B was a 33-year-old patient who presented 3 years ago with panhypopituitarism following transsphenoidal surgery in 2012, for a sellar mass in a foreign country. She had already commenced 5mg prednisolone daily in addition to DDAVP, levothyroxine and the COCP. Having noticed mild weight gai...

Introduction: Beckwith-Wiedemann syndrome (BWS) is characterized by hyperinsulinaemic hypoglycaemia (HH), overgrowth, tumour predisposition and congenital malformations. Commonly, BWS is caused by epigenetic or genomic alterations, which disrupt genes in one or both of the two imprinted domains on chromosome 11p15.5. Rarely (~1%), paternally inherited duplications of 11p15 can result in BWS phenotype. We describe the first case of BWS associated with a paternally inherited dup...

Recent data indicate that steroid action can be completed through genomic (late) and non-genomic (rapid) mechanisms. Non-genomic androgen effects are initiated at the membrane level and imply specific secretory and signaling mechanisms different from the classical intracellular androgen receptor activation. In previous work we have reported that androgen membrane binding sites (Ambs) are present in LNCaP human prostate cancer cells. Their activation mediates a FAK/PI3K/Cdc42/R...

Background: Before radioiodine (RAI) therapy patients undergo a technetium 99m thyroid uptake scan and anti-thyroid medication is stopped prior to treatment following clinical review with the nuclear medicine team. Once treated, patients are followed up in the post-radioiodine telephone clinic. Thyroid function is checked at 3, 6, 9 and 12 weeks. Levothyroxine is started once the fT4 is <14 pmol/l.Purpose: To assess ...

A 36-year-old Caucasian male was referred in November 2021 to our clinic, for investigations regarding his recent genetic diagnosis of congenital hyperinsulinism, revealed by genetic testing, performed after the birth of couple’s second child presenting with recurrent hypoglycemia.The female newborn diagnosed with fetal macrosomia (birth at 38 weeks, 4.3 kg), required follow-up and further examinations.A massive parallel sequencing on panel of 4867 genes using Roche platf...

Introduction: The classical triad of pheochromocytoma comprises paroxystic headache, palpitation, and diaphoresis. It is a common cause of secondary hypertension. Glycemic abnormalities are not rare. Hyperglycemia and diabetes can be the presenting features of pheochromocytoma. However, cases of hypoglycemia are also described. Malignant tumors account for about 10% of cases.Case description: In this report, we present a case of a 41-year-old man referre...