Searchable abstracts of presentations at key conferences in endocrinology

ea0020p528 | Paediatric Endocrinology | ECE2009

Childhood obesity and bone age

Petrou Vassilios , Tertipi Athanasia , Georgoulas Thomas , Papastathi Eleni , Deligeorgi Maria , Skarpa Vassiliki , Papathanasiou Asteroula

Obese children frequently present with accelerated growth and early puberty.Objective: To examine the degree of bone maturation in children with simple obesity.Patients and methods: One hundred eighteen boys with mean chronological age (CA) 9.9±2.2 years (3–13 years) and 102 girls with CA 8.4±2.0 years (3–12 years) with simple obesity (BMI>97th centile for age and sex) were studied. Ninety-five children were...

ea0016p112 | Clinical cases | ECE2008

Children with growth retardation due to Rathke cleft cyst

Petrou Vassilios , Papachilleos Petros , Valvis Nikolaos , Ioannidis Dimitrios , Tertipi Athanasia , Georgoulas Thomas , Chadjiathanasiou Charalambos , Papathanasiou Asteroula

Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke’s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are >1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifestin...

ea0016p725 | Thyroid | ECE2008

Treatment with thyroxine reduces thyroid volume in euthyroid children with Hashimoto thyroiditis

Scarpa Vasiliki , Kousta Eleni , Tertipi Athanasia , Ioannidis Dimitris , Petrou Vasilis , Chatziathanasiou Charalambos , Papathanasiou Asteroula

Introduction: There is no concensus whether euthyroid children with Hashimoto’s thyroiditis (HT) need treatment with thyroxine.Aim of the study: To assess whether thyroxine influences goitre progression (calculated thyroid volume on U/S scan) in euthyroid children with HT.Subjects and methods: We studied 50 euthyroid children with HT for a 2-year period. Children with a multinodular goitre were not included in the study. Twent...

ea0014p441 | (1) | ECE2007

An 8-year-old boy with seizures and hypokalemia due to a paraganglioma

Petrou Vassilios , George Kolofotis , Georgouli Eleni , Papathanasiou Asteroula , Athanasia Tertipi , Stefanidis Constantinos , Hadjiathanasiou Charalambos

Pheochromocytomas and paragangliomas, tumors originating from the chromaffin cells, are rare in children.We report an 8-year-old boy who was admitted to the intensive care unit with seizures for which the child had to be intubated, severe hypokalemia (1.8 mEq/l), hyponatremia (127 mEq/l) and fever. Parents reported that several months before admission the boy had nocturnal sweating. Brain MRI revealed areas of increased sign intensity in the parietal lob...

ea0011p352 | Diabetes, metabolism and cardiovascular | ECE2006

Association of an insertion/deletion polymorphism in the alpha 2B adrenergic receptor with essential hypertension in diabetic patients

Papazoglou DP , Papatheodorou KP , Papanas NP , Papazoglou LP , Papathanasiou PP , Exiara TE , Christakidis DC , Maltezos EM

Background: The alpha2B adrenoceptor gene, a candidate gene for essential hypertension, harbours a functional insertion/deletion (I/D) polymorphism of three glutamate residues.Objectives: The aim of this study was to investigate whether the presence of the D allele is associated with hypertension in Greek patients with type 2 diabetes mellitus (T2DM).Patients-methods: One hundred and twenty-nine hypertensive (64 male, mean age: 66....

ea0026p320 | Obesity | ECE2011

Low birth weight and obesity are associated with increased androgen levels among children with premature adrenarche

Lekka L , Kousta E , Anyfandakis K , Leka S , Papathanassiou A

Introduction: The aim of the study was to assess the impact of obesity and birth weight (BW) at diagnosis of premature adrenarche (PA) in a large cohort of greek children.Methods/design: We assessed clinical and laboratory characteristics of 221 children (175 girls and 46 boys) at diagnosis of PA.Results: At diagnosis of PA 149 children (67.4%) had pubic hair (Tanner stage ≥2), 10 (4.5%) had axillary hair (Tanner stage &#8805...

ea0014p199 | (1) | ECE2007

Overconsumption of salty and sweet foods increases blood pressure in children

Petrou Vassilios , Tertipi Athanasia , Papathanasiou Asteroula , Zerva Ourania , Skarpa Vassiliki , Papachilleos Petros , Anastasacou Marina , Nicolopoulos Panagiotis , Hadjiathanasiou Charalambos

Aim: To estimate the impact of overconsumption of salty and sweet foods on Body Mass Index (BMI) and Blood Pressure (BP) in children.Patients-Methods: We studied 208 children (105 girls), aged 9.2±3.0 yr, 57 (27.4%) of normal weight, 37 (17.8%) overweight and 114 (54.8%) obese. Overconsumption of NaCl was considered >5 g/day and of free sugar >0.5 g/Kg ideal Body Weight/day. BP was measured as appropriate and BMI was estimated in all childre...

ea0011p901 | Thyroid | ECE2006

Hashimoto’s thyroiditis in the children: clinical features at presentation

Skarpa VT , Kostakioti ED , Tertipi AK , Petrou PA , Posnaghidou E , Anastasakou M , Papahilleos P , Papathanasiou A , Hadjiathanasiou C

Hashimoto’s thyroiditis (HT) is the most frequent thyroid disease in children, in areas of the world with sufficient iodine intake.Aim: To study the clinical features of HT in children at presentation.Material and method: We studied 99 children with HT, 76 (76.8%) girls and 23 (23.2%) boys, with mean chronological age 10.7±2.6 ys (3.2–15.6 ys). The diagnosis of HT was established from the high titers of antithyroid a...

ea0032p815 | Paediatric endocrinology | ECE2013

Growth disorders in Greece: baseline data from a multicentre observational study (GENESIS)

Aloumanis Kyriakos , Karachaliou Feneli , Vlachopapadopoulou Elpis , Michalacos Stephanos , Papathanasiou Asteroula , Chrysis Dionysis , Stamoyannou Lela , Karis Christos , Spiliotis Bessie , Drossinos Vangelis , Chrousos George

Aim: The Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) is an open-label multinational observational study which collects information on management, clinical outcomes and treatment safety of children with growth disorders. Here we present descriptive data from the Greek cohort.Methods and results: In Greece, 211 children (44.5% females, 136 naive to GH treatment at study entry and 18 not GH-treated) have been enrolled, aft...

ea0016p703 | Thyroid | ECE2008

Results of thyroxine therapy on thyroid nodules size in children with Hashimoto's thyroiditis

Skarpa Vassiliki , Tertipi Athanasia , Petrou Vassilios , Kostakioti Eleni , Posaghidou Elvira , Kousta Eleni , Papachilleos Petros , Kitsopoulou Aphroditi , Vakaki Marina , Fotinou Aspasia , Ioanidis Dimitris , Papathanasiou Asteroula , Hadjiathanasiou Charalambos

Aim: To study the effect of thyroxine treatment on the size of thyroid nodules in children with Hashimoto’s thyroiditisPatients and methods: Twenty-two girls and 6 boys (78.6/21.4%) were followed for 2 years under thyroxine therapy, at mean dose 1.6±0.4 μg/kg per day. Diagnosis of Hashimoto’s thyroiditis was based on the high value of either antithyroid antibodies, ATPO or ATG. Age at presentation was 10.6±2.0 year (6.2–13.6...