Endocrine Abstracts

Idiopathic hypogonadotropic hypogonadism (IHH) is caused by an isolated defect in GnRH release or action and classified as the Kallmann syndrome with associated anosmia or normosmic IHH in the presence of a normal sense of smell. Patients with IHH have absent or incomplete sexual maturation and infertility. Usually long term GnRH or gonadotropin therapy in these patients can induce spermatogenesis and puberty and is followed by testosterone therapy to maintain normal virilizat...

About 8–10% of erectile dysfunction (ED) is caused by hormonal causes, but in men over 65 years testosterone deficiency due to aging seems to play important role. In population of Polish men with relative poor health status, the prevalence of testosterone deficiency in elderly men with ED is probably higher. We evaluated the prevalence of low and low-normal testosterone levels in men with ED in population of Polish men over 65 years.Material and met...

Objectives: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEAS levels and angiographically verified coronary heart disease (CHD).Material and methods: The study included thirty men aged 41–60 years (mean age 52±0.90 yr) with serum DHEAS concentration <2000 μg/l, who were...

Introduction: In elderly men testosterone and DHEAS deficiency is often observed, also changes of body composition and metabolic disturbances are common disorders.Objectives: The aim of this study was to analyze the association between testosterone and DHEAS deficiency and waist/hip ratio (WHR) and also levels of glucose, insulin, HOMA and FG/FI ratio in elderly men as well as analysis, whether these sex hormones influent on measured parameters separatel...

A 76-year obese women with diabetes mellitus t II, hypertension and urolithiasis was referred to our clinic for reason of high cortisol levels, which were detected in regional hospital, two days after cystoscopy and catheterization of right ureter. Cortisolemia was 35 μg% at 8.00 and 37 μg % at 22.00. Short dexamethasone test didn’t cause cortisol suppression (cortisolemia after 1 mg DXM was 27 μg %). After two days of dexamethasone (4×2 mg) blood cort...

In 100 consecutive osteoporotic women referred to our clinic we assessed 25OHD3 and PTH levels. Patients suffered from postmenopausal osteoporosis and intolerance of oral bisphosphonates, were treated at least for 6 months with calcium and vitamin D. The reasons of intolerance of oral medication were gastritis (53), esophagitis (18) or peptic ulcer (29 cases). Patients were therefore chronically treated with proton pump inhibitors (PPI). They were referred to our Clinic in ord...

Autoimmune destruction of the adrenocortical cells is the most frequent form of Addi-son’s disease, however modern imaging methods make possible to discover bilateral neoplastic laesions resulting in adrenal insufficiency more frequently than about twenty years ago. In our group of 315 patients with Addison’s disease we diagnosed metastatic infiltrations of the adrenals in 18 cases and lymphoma of both adrenals in four cases (in sum 7%). Typical clinical signs, bioch...

Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are weak adrenal androgens, which may exert anabolic effect on bone tissue.We have measured serum DHEAS levels and bone mineral density in lumbar spine and femoral neck in 131 healthy, agile, postmenopausal women aged 59–89. There were no diseases which aggravate bone loss and no hormonal replacement therapy in medical history of participants.Women were divided into groups...

Cushing’s syndrome is associated with life-threatening complications, as well as high rates of perioperative mortality and morbidity. Authors present clinical scenarios, in which one should consider the usage of intravenous etomidate as an accurate, safe and effective drug for hypercortisolaemia.Case 1: 23-year-old female with severe Cushing’s syndrome due to metastatic adrenocortical carcinoma was admitted to the Department of Endocrinology. S...

Presence of clinical symptoms and signs specific for suspected illness is, in general, a condition sine qua non to start diagnostics procedures. However, some diseases may proceed with various and disparate symptoms, which often suggests completely different diagnosis. One of them is pheochromocytoma – rare, usually benign neoplasm derived from chromaffin cells of adrenal medulla. It is very important to diagnose the disease while it is curable by surgery like ma...