Searchable abstracts of presentations at key conferences in endocrinology

ea0028p363 | Thyroid | SFEBES2012

The number of positive lymph nodes in the central compartment has no prognostic impact in papillary thyroid cancer

Parameswaran Rajeev , Sadler Gregory , Mihai Radu

Background: Papillary thyroid cancer (PTC) metastasizes to central compartment lymph nodes (CCLN) in majority of patients. Such metastases are associated with high risk of locoregional recurrence and distant metastasis. Only one study has investigated the relation between the number of metastatic CCLN and prognosis (Soon Lee et al. 2010 WJS). This study evaluated the clinical implication of the number of metastatic CCLN in PTC.Methods: Between Jan...

ea0025p73 | Clinical biochemistry | SFEBES2011

Introduction of day-case thyroid and parathyroid surgery has allowed achievement of the shortest length-of-stay in the United Kingdom

Parameswaran Rajeev , Sadler Gregory , Mihai Radu

Background: Length-of-stay (LOS) after various surgical procedures varies greatly between centres and countries. In the US there is increasing tendency towards day-case thyroid and parathyroid surgery but their model of care cannot be easily extrapolated. In the UK the average LOS for such operations is 3–4 days.Methods: Retrospective review of data retrieved from hospital-based software regarding the surgical activity during a decade in a large Uni...

ea0011p488 | Endocrine tumours and neoplasia | ECE2006

Multiple Endocrine Neoplasia Type 1 (MEN 1) is associated with insulin resistance and an increased prevalence of diabetes and impaired fasting glucose

McCallum RW , Parameswaran V , Burgess JR

MEN 1 is an autosomal dominant syndrome associated with benign and malignant neuroendocrine neoplasia. It is characterised by primary hyperparathyroidism, pituitary neoplasia and foregut lineage neuroendocrine tumours. It has also been associated with premature cardiovascular death. Since diabetes is associated with an increased risk of cardiovascular mortality we investigated the prevalence of diabetes (DM) and impaired fasting glucose (IFG) in a large cohort of patients with...

ea0094p200 | Endocrine Cancer and Late Effects | SFEBES2023

SURvey of Surgeon’s and Physician’s experiences of GEnetic testing in patients with Familial Endocrine Syndromes: SurGe in UK and Abroad

de Jong Mechteld , Parameswaran Rajeev , Kurzawinski Tom

Introduction: Genetic testing for Familial Endocrine Syndromes has an important role in diagnosis, timing/extent of surgery, and follow-up. Our survey explored experiences and attitudes towards genetic testing in the UK and Abroad.Methods: Attendees of 2022 Conferences of ESES, BSPED, SfE, BAETS and AsianAES were asked to participate in an online survey (31 questions on demographics; genetic testing availability and expe...

ea0028p3 | Bone | SFEBES2012

Outcome of patients with negative neck exploration for primary hyperparathyroidism

Parameswaran Rajeev , Gleeson Fergus , Sadler Gregory , Mihai Radu

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disease expected to be curable in 95% of patients undergoing surgical treatment. The aim of this study was to assess the postoperative course of patients with failed surgical treatment.Methods: Prospective database recorded clinical, biochemical, radiological, operative and pathological details of patients operated in a large tertiary referral centre.Results: Betw...

ea0021p212 | Endocrine tumours and neoplasia | SFEBES2009

Routine central compartment lymph node dissection for papillary thyroid cancer has minimal impact on early postoperative parameters

Parameswaran Rajeev , Stechman Michael , Weaver Andrew , Sadler Gregory , Mihai Radu

Background: Arguably patients undergoing total thyroidectomy for papillary thyroid cancers (PTC) are more likely to have negative radioactive iodine uptake and low/undetectable thyroglobulin levels if the central compartment lymph node dissection (CCLND) is performed routinely irrespective of the macroscopic appearance of the LN. The aim of this study was to determine whether routine CCLND leads to more favourable outcome in the first year after treatment for well-differentiat...

ea0011p78 | Clinical case reports | ECE2006

Synchronous malignant para-aortic phaeochromocytoma and vagal nerve paraganglioma in a patient with germline SDHB mutation

McCallum RW , Stanton P , Walker S , Parameswaran V , Greenaway T

Phaeochromocytomas and paragangliomas arising as part of familial syndromes such as multiple endocrine neoplasia (MEN)2 or von-Hippel Lindau syndrome (VHL) are more likely to be malignant and multiple. Recently the role of mutations in the SDH genes (encoding subunits of succinate dehydrogenase) have also been identified as important in the aetiology of such tumours. We report a case where identification of an apparently sporadic metastatic phaeochromocytoma was found to be co...

ea0077p150 | Adrenal and Cardiovascular | SFEBES2021

Crescendo renal failure: an unusual presentation of Addison’s disease

Head Simeon , Parameswaran Madhangi , Wood Ffion , Williams Elin , Tellier Genevieve , Wilton Anthony

The non-specific symptoms of Addison’s disease may be attributed to other conditions with consequent delay in diagnosis. We describe such a case of novel presentation. A 61 year old female presented with a one-day history of vomiting, abdominal pain and 15kg weight loss over 6 months. PMH: hypertension of 15 years duration, chronic kidney disease (CKD3) for 7 years and hysterectomy for endometrial carcinoma 8 years earlier. Examination: dehydrated, sinus tachycardia 110 b...

ea0086p314 | Bone and Calcium | SFEBES2022

Appropriateness of parathyroid imaging in patients with primary hyperparathyroidism

Subramanian Parameswaran Sathvikha , Mahankali-Rao Preeti , Hogg Stephen , Kerry Joanne , Chinnusamy Ravikumar

Aim: To assess the appropriateness of parathyroid imaging performed in patients with primary hyperparathyroidism at the United Lincolnshire Hospital NHS Trust from 2018 to 2019.Background: Primary hyperparathyroidism (PHPT) is a clinical and biochemical diagnosis. Reported sensitivity for imaging localisation of parathyroid adenomas for ultrasound and sestamibi scans are not high at 65 to 85% and 71 to 92%, respectively. Surgeons use combined ultrasound ...

ea0031p366 | Thyroid | SFEBES2013

A rapidly enlarging neck lump and Horner's sign: lessons from a novel case

Donaldson James Fergus , Booth Frank , Parameswaran Rajeev , Rodriguez Gomez Iria Adriana

Background: Anaplastic carcinoma and primary lymphoma (TL) each constitute <2% of thyroid malignancies and are difficult to distinguish clinically. Both typically present with rapidly enlarging anterior neck masses in the elderly. Both may cause pressure symptoms (e.g. dysphagia, stridor and hoarseness). Differentiation is imperative as their treatment and prognoses differ.Case report: A 68-year-old man presented with a rapidly enlarging thyroid mass...