Endocrine Abstracts

Oestrogen replacement therapy remains one of the two licensed indications for the use of HRT. The rationale is sound. Oestrogen is from the time of puberty a major regulator of the resorption/formation balance and of the rate of recruitment of BMUs. Natural or surgical withdrawal of oestrogen results in acceleration of turnover, bone loss and potential osteoporosis. Similarly, in the postmenopause, restoration of oestrogen to premenopausal levels restrains turnover, inhibits r...