Endocrine Abstracts

Introduction: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders characterized by bradykinesia, tremor, rigidity and postural instability as well as neurocognitive impairment and depression. Studies found a significant association between thyroid dysfunction and an increased risk of PD. We report the case of a patient treated for PD who had also Hashimoto’s thyroiditis, and we discuss the association of thyroid dysfunction with risk of PD....

Introduction: Parkinson’s disease is considered the most common chronic neurodegenerative disease that often affects the elderly, rarely the young. Meanwhile, Diabetes mellitus is the most common chronic metabolic disease. Because of the increase in the prevalence of diabetes and neuro-vegetative diseases, we can wonder about the relationship between the two diseases. We report the case of a patient with type 2 diabetes mellitus associated with young onset Parkinson’...

Objective: Despite combination with peripheral decarboxylase inhibitors significant amounts of L-dopa are peripherally metabolised. In patients with Parkinson’s disease (PD) treated with L-dopa and a dopa decarboxylase inhibitor, urinary dopamine concentrations are markedly elevated. We describe here a L-dopa treated PD patient presenting with a clinical and biochemical picture suspicious of phaeochromocytoma.Case report: A 73-year-old female patien...

Dopamine agonists can falsely elevate plasma and urinary metanephrines, thus making the diagnosis of pheochromocytomas in patients taking these medications challenging. We present the case of an 80-year-old female care home resident with a background of hypertension, Parkinson’s disease (PD), dementia and pernicious anaemia. She presented with weight loss, unilateral leg swelling and abdominal distension. A computed tomography (CT) showed a 5.6 cm heterogeneously enhancin...

Epidemiological and clinical studies provide evidence for sex differences in the incidence or severity of certain neurological conditions. For example Parkinson's disease, which is characterised by a progressive degeneration of dopaminergic (DA) neurones in the substantia nigra pars compacta (SNc) and a reduction in DA levels in the striatum, is more prevalent in men than women. Therefore, our work aimed to establish whether physiological levels of sex steroid hormones confer ...

We describe case of 50-year patient with poliomyelitis in childhood, no other concomitant ilnesses, admitted in 2010 to neurologic departement of our hospital for grave parkinson-like syndrom with loss of motor function, symetric quadruparesis with spasticity, epileptic seizures and mental deterioration. These problems started about 12 months before and progressively worsened, patient was treated by levodopa and primidone. Patient was after bilateral intraocular lens implantat...

Background: There is growing evidence that ergot dopamine agonists (DA) may induce cardiac valve regurgitation (CVR) in persons with Parkinson’s disease (PD). It is unclear whether the CVR risk is increased with ergot-DA use in persons with hyperprolactinemia, in whom the dose is much lower.Objective: To assess the association between ergot and non-ergot DAs and CVR in patients with hyperprolactinemia and PD.Methods: Nested ca...

Objective: We studied the prevalence of endocrine dysfunction in subjects with idiopathic Parkinson’s disease (IPD) on newer dopaminergic agents (DA). DA are used in endocrine hypersecretory states in small doses and we hypothesized that endocrine dysfunction was likely in IPD where DA was used in comparatively much higher dosage.Patients and methods: 25 subjects with IPD on DA for were recruited to this cross-sectional study. We measured IGF1, prol...

IntroductionIn general, the risk to develop Parkinson’s disease (PD) is higher in men compared to women. Besides male sex and genetics, research suggests diabetes mellitus (DM) is a risk factor for PD as well. In this population-level study, we aimed at investigating the sex-specific impact of DM on the risk of developing PD.Research design and methodsMedical claims data were analyzed in a cross-sectiona...

Background: An estimated 462 million individuals are affected by type 2 diabetes mellitus (T2DM), corresponding to 6.28% of the world’s population. Many epidemiological studies have indicated that T2DM may be a risk factor for neurodegenerative diseases, including Parkinson’s disease (PD). Whilst research suggests there are common molecular mechanisms underlying the conditions, studies investigating the epidemiological association have revealed conflicting res...