Endocrine Abstracts

Background: Diet modification is an important part of the metabolic syndrome’s management but there is limited data regarding a direct relationship between food groups and the metabolic profile.Aim: Evaluation of the influence of food groups on the elements of metabolic syndrome in a group of subjects with abdominal obesity.Material and methods: A cross sectional study was conducted in the Endocrinology Outpatient Clinic betwe...

Introduction: The association between medullary (MTC) and differentiated thyroid cancer (DTC, with the most frequent form of papillary thyroid carcinoma, PTC) is rare and can be observed in two main settings: a collision tumor (that is, a tumor with two separate and different components) or a mixed tumor showing dual differentiation.Case report: A 58-year-old woman, affected by euthyroid multinodular goiter came to our observation for a second opinion re...

Introduction: The thyroid is a multifaced endocrine gland. By its hormones it has an effect on almost all organs of the body, metabolism and defence system too. The relationship between the thyroid hormones and the nonspecific defence system has been less studied.Aim: To study and prove whether the endogenous thyroxin (FT4) is involved in the nonspecific defence system of the organism. We followed the correlation between the FT4 and...

Introduction: The thyroid is a multifunctional endocrine gland which, by its hormones, affects all the organs, metabolisms and nonspecific defence of the body. The aim of this study is to establish if endogenous thyroxin (FT4) is involved in the nonspecific defence of the organism.Material and methods: 94 patients were included in the study, 47 with hyperthyroidism and 47 with hypothyroidism, 81 women, 13 men aged 7–78. FT4 was...

Introduction: The diagnostical and therapeutical management of GH-secreting pituitary adenomas has been modified in many aspects in the last decade, and the guidelines also have been considerably changed.Objective: To evaluate the management of acromegaly applied in an endocrinological clinical unit from Romania, and the efficiency of different therapeutical schemes.Materials and methods: 23 patients with acromegaly, treated and fo...

Objective: To study the efficacy of lithium and perchlorate in special cases of hyperthyroidism: thioamide-resistant or iodine-induced thyroxicosis/thyrotoxic pre-crisis, hematological adverse effects of methimazole, leukopenia of other causes.Material and methods: Twenty-seven hyperthyroid patients received lithium carbonate and/or potassium perchlorate, majority after methimazole-therapy (associated with folic acid in leukopenia). We followed the clini...

Thyroid-associated ophtalmopathy (TAO) is an organ-specific autoimmune process that is strongly associated with thyroid dysfunction. Patients with TAO may present eyelid retraction, proptosis, chemosis, periorbital oedema and altered ocular motility with significant functional and cosmetic consequences. There is the possibility of coexistence of two or more autoimmune diseases affecting the eye due to the cross-reactivity to common antigens from the eye muscles.<p class="a...

Introduction: We report a case of Cushing’s syndrome association with nephrotic syndrome in a patient with occult ectopic ACTH (EAS) secretion by a bronchial carcinoid and resolution of both disorders after bilateral adrenalectomy.Case report: A 42-year-old man was admitted to our department with the suspicion of EAS. He was in a very good health until several months ago when he developed suddenly nephrotic syndrome, severe hypertension, severe hypo...

Introduction: Even mild to moderate maternal iodine deficiency during pregnancy is associated with impaired child cognition. Iodine deficiency is especially problematic in pregnant women, who have a higher iodine requirement (250 μg/day) than non-pregnant women (150 μg/day).Objective: To assess iodine status (median urinary iodine concentration, UIC) in pregnant women from multiple endemic or non-endemic areas in Romania, 13 years after impleme...

Introduction: Nijmegen breakage syndrome(NBS) represents a rare autosomal recesive disorder, characterized by severe chromosomal instability. It is caused by mutations in the NBN gene, which product, nibrin, belongs to the hMre11/hRad50 protein complex, critical for processing DNA double-strand breaks during mitotic and meiotic recombination. The hallmarks of NBS are growth retardation, microcephaly, premature ovarian failure(POI) in females, immunodeficiency and predispositio...