Searchable abstracts of presentations at key conferences in endocrinology

ea0049cet1 | Clinical Endocrinology Trust Lecture | ECE2017

Prospects for a new assessment of polycystic ovarian syndrome

Pasquali Renato

PCOS is the most common hyperandrogenic disorder, with a high prevalence of metabolic comorbidities, including obesity and central fat distribution, insulin resistance and the metabolic syndrome. With this background, it should be accepted that androgen excess must be present in all women with PCOS. Thanks to the advance in measuring blood androgen levels by LC-MS/MS, it has become clear that almost all typical cases of PCOS have a variable pattern of androgen excess. An andro...

ea0035s6.3 | Focus on novel developments of PCOS conclusions from the PCOS Task Force | ECE2014

Focus on novel developments of PCOS: conclusions from the PCOS Task Force: treatment of PCOS

Pasquali Renato

A recent questionnaire aiming to understand which is the practice on diagnosis and management of polycystic ovary syndrome (PCOS) has been sent to all members of ESE. More than 13% of members of ESE participated in the survey. The main results were the following: i) the NIH criteria are followed by the majority of respondents; ii) obesity and type 2 diabetes were regarded as the principal long-term concerns, whereas much less concern was given to infertility; iii) the most com...

ea0032s18.3 | PCOS | ECE2013

The diagnosis of PCOS in adults: new biomarkers

Pasquali Renato

The National Institute of Health (US) recently organized an Evidence-based Methodology Workshop on the polycystic ovary syndrome (PCOS), focused on definition of the syndrome. Among others, the conclusions included the following: i) the need to assign a name that reflects the complex interactions that characterize the syndrome; ii) it is advisable to maintain a broad, inclusionary diagnostic criteria of Rotterdam, while specifically identifying the most common phenotype, chara...

ea0020s1.2 | PCOS | ECE2009

Targeting insulin sensitivity in the treatment of PCOS

Pasquali Renato

Lifestyle interventions and insulin sensitizers play a fundamental role in the treatment of PCOS, particularly in the presence of obesity. The rationale is represented by the reasoning that the decrease in insulin concentration, as a result of improved insulin resistance, may lead to metabolic alterations and have important effects on hyperandrogenism, and, in particular, on fertility. Insulin sensitizers can be added to lifestyle intervention, when obesity is present, althoug...

ea0014s11.4 | Polycystic ovary syndrome | ECE2007

Individual pharmacological therapy for polycystic ovary syndrome: lessons from the phenotype

Pasquali Renato

Hyperandrogenism, hyperinsulinemia and insulin resistance are the cardinal features of most women with the polycystic ovary syndrome (PCOS). They contribute in different ways to its phenotypic expression, including hirsutism, menses abnormalities, oligo-anovulation, metabolic disturbances, and susceptibility to develop type 2 diabetes. From the theoretical point of view, individual pharmacotherapy of PCOS should be planned in order to counteract the main pathophysiological mec...

ea0037ep976 | Thyroid (non-cancer) | ECE2015

Efficacy of two different L-thyroxine formulations in dyspeptic patients with subclinical hypothyroidism

Ribichini Danilo , Vaira Berardino , Pasquali Renato

Levo-thyroxine (LT4) formulations are available on tablets (TAB) or liquid solution (SOL). LT4 TAB absorption could be affected by several gastric diseases as Helicobacter pylori (HP) infection or chronic atrophic gastritis (CAG), instead no data are available on absorption of the LT4 SOL in these conditions. The aim of the study was to compare the efficacy of TAB or SOL LT4 formulations in patients with dyspeptic syndrome (DS) and subclinical ...

ea0081p297 | Calcium and Bone | ECE2022

Phenotype characterization of a PHEX non canonical splice-site mutation in a family affected by X linked hypophosphatemic rickets and efficacy of one-year Burosumab treatment in adult patients

Di Fraia Rosa , Digitale Selvaggio Lucia , Allosso Francesca , Pasquali Daniela

X-linked hypophosphatemic rickets (XLH) is associated with mutations in PHEX, upregulation of FGF23, leading to hypophosphatemia, abnormal bone development and short stature. H-MAB to FGF23, Burosumab, is the new therapy for XLH. Among PHEX mutations, c.1586+6T >C, partially destroying the splice-site, is presumably associated to a mild phenotype not described so far. We describe two siblings bearing the PHEX c.1586+6T >C variant. Cas...

ea0070aep65 | Adrenal and Cardiovascular Endocrinology | ECE2020

Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia

Esposito Daniela , Johannsson Gudmundur , Ragnarsson Oskar , Pasquali Daniela

Context: Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular diseases. The mechanisms for this is unclear.Objective: To assess cardiovascular structure and function in AI patients on conventional replacement therapy and after switching to once-daily, modified-release hydrocortisone (OD-HC).Methods: The analysis included 17 adult AI patients (11 with primary AI, 7 with secondary...

ea0032p731 | Obesity | ECE2013

Brite adipocytes: a role for cannabinoid receptor type 1 in brown adipose cell recruitment

Mazza Roberta , Quarta Carmelo , Pasquali Renato , Pagotto Uberto

Recent data showed the existence of a specific adipocyte population composed of ‘brite’ cells in white adipose tissue (WAT), characterized by a peculiar gene expression pattern including PRDM16. Despite showing a low basal UCP1 expression, these cells display higher UCP1 expression when stimulated. In view of the involvement of the endocannabinoid system in energy homeostasis, the aim of our work is to establish whether the CB1 receptor could be a target for brown ph...

ea0029p939 | Female Reproduction | ICEECE2012

AMH and INSL3 levels in ovulatory and anovulatory women with the polycystic ovary syndrome

Pelusi C. , Gambineri A. , Fanelli F. , Pariali M. , Pasquali R.

Introduction: Anti-Mullerian hormone (AMH) and insulin-like factor 3 (INSL3) represent ovarian functional markers of granulosa and theca cells respectively. This study investigated AMH and INSL3 plasma levels in two groups of ovulatory or anovulatory women with polycystic ovary syndrome (PCOS), and their relationship with ovarian morphology and androgen levels.Methods: AMH and INSL3 were measured in a cohort of 57 patients with PCOS classified in two gro...