Endocrine Abstracts

Introduction: Sirolimus, a mTOR (mechanistic Target of Rapamycin) inhibitor, is well known for its impact on glucides and lipids metabolism. These effects vary according to factors such as dose and treatment duration, species, cell types and environmental factors. In vitro and in vivo, sirolimus inhibits adipogenesis by decreasing adipocytes number and size, as well as pre-adipocytes differentiation, leading to subcutaneous and visceral fat mass decrease in m...

Introduction: There are few data on renal function following bariatric surgery. We evaluated the effect of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) on renal function over a 5-year post-operative period. We also evaluate the effect of these procedures on remission of diabetes and hypertension.Methods: Analysis of a prospectively collected database at Lille University Hospital. Patients were assessed pre...

This study describes the evolution of retinopathy 5 years after islet transplantation (IT) with the Edmonton protocol in type 1 diabetic patients. Before IT and then yearly for 5 years, 21 patients (13 islet-alone (ITA), 8 islet-after-kidney (IAK)) underwent monitoring of laboratory parameters, continuous 24 h mean blood pressure (24h BP) and 72 h glucose (CGM), as well as complete ophthalmologic examination. Ten of the 21 patients (48%) were insulin-independent 5 years post-I...

Context: The influence of beta cell replacement on daily glucose profile in Type 1 diabetes mellitus (T1DM) is not firmly established.Objective: To examine the influence of islet transplantation (IT) on the various component of dysglycemia in T1DM patients.Design, setting and patients: Single arm open labeled study. Twenty-three consecutive patients with T1DM, 11 males and 12 females, 14 non uremic and 9 uremic with a previous kidn...

Background: Weight gain in type 1 diabetes (T1D) patients has become a clinical problem due to less strict diets and more stringent glycemic targets. Thus, the number of overweight T1D in the USA increased from 3.4% in 1988 to 22.7% in 2007. Hyperinsulinism is involved in the genesis of obesity but in T1D, the impact of insulin therapy in weight gain is not established. Islet transplantation, now reimbursed in France, makes it possible to interrupt insulin. The aim of this wor...

The aim of this retrospective study was to compare the long-term evolution of adrenal insufficiency (AI) due to bilateral adrenal surgery (S) or medical cause (M).Seventy AI patients (mean age 41±16 years; 60% female, similar in both groups) were followed during a mean 6-year period (2–16); 38 were AI after bilateral adrenalectomy (60% Cushing), 32 AI of medical origin (62% polyglandular autoimmune syndrome). BMI, blood pressure (BP), fasting b...

CYP24A1 gene encodes 24-hydroxylase that inactivates 1-25-OHvitaminD. Mutations induce infantile hypercalcemia, with high 1-25-OHvitaminD, contrasting with low PTH levels. Adult phenotypes are not well known yet. We report two cases of post-surgical persistent hypercalcemia, related to CYP24A1 mutations. Two unrelated patients, a 40-year-old female (#1) and 54-year old male (#2), were referred for nephrolithiasis, enthesis and hypertension in both, associated...

Objectives: Sirolimus inhibits adipocyte differentiation (Yeh PNAS 1995). This study compares weight and fat markers in two groups of patients treated or not with sirolimus, before and after transplantation.Patients and method: Nineteen islet-alone transplanted patients treated with sirolimus and 7 islet-alone or liver-transplanted patients NOT treated with sirolimus were compared 1 year after transplantation in terms of weight, fat mass (equation of bod...

Background: Locoregional nodal metastases are the first step of tumor spread in MTC and have been shown to be a prognostic factor for survival. Neither palpation nor neck ultrasound can estimate nodal staging accurately.Aim: To identify predictive factors for LNI in MTC through a retrospective study on 142 consecutive patients operated in Lille University Hospital between 1995 and 2010.Methods: Analyses were carried on 54 patients ...

Von Hippel Lindau disease (VHL) induces tumors of kidneys, central nervous system, pancreas and paragangliomas We report one case where ectopic Cushing syndrome revealed VHL. A 19-year old was referred for hirsutism and spaniomenorrhea revealing an ACTH-dependent Cushing syndrome. Mineralocorticoids, calcium metabolism, chromogranine A, calcitonine, pancreatic hormones and urinary 5-HIA were normal. Blood nor- and metanephrine were 5.12 μg/l (n<5) and 0.92 &#95...