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ea0011p414 | Diabetes, metabolism and cardiovascular | ECE2006

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with increased type-2 diabetes mellitus prevalence

Heald AH , Stephens RH , McElduff P , Kaushal K , New JP , Worthington J , Ollier WE , Pendleton N , Horan M , Payton A , Gibson JM

Introduction: Dysregulation of the Insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF-binding protein 1 (IGFBP-1) has been implicated in the aetiopathogenesis of obesity, diabetes mellitus and such complications such as cardiovascular disease and nephropathy. However, relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP1...

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ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 4079 in eight ...

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ea0029oc11.5 | Thyroid Clinical 2 | ICEECE2012

Thyroid hormones and male sexual function

Corona G. , Frederick W. , Forti G. , Lee D. , O'Connor D. , O'Neill T. , Pendleton N. , Bartfai G. , Boonen S. , Casanueva F. , Finn J. , Giwercman A. , Thang H. , Huhtaniemi I. , Kula K. , Lean M. , Punab M. , Vanderschueren D. , Jannini E. , Mannucci E. , Maggi M.

Objective: The role of thyroid hormones in the control of erectile functioning has been only marginally investigated. The aim of this study is to investigate the association between thyroid and erectile function in a general population sample (European Male Aging study, EMAS study) and in patients seeking medical care for sexual dysfunction (University of Florence Study, UNIFI study).Participants: Two different cohorts of subjects were evaluated. The fir...

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Endocrine Abstracts

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with increased type-2 diabetes mellitus prevalence

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Thyroid hormones and male sexual function

BiosciAbstracts