Endocrine Abstracts

Renin is a rate-limiting enzymatic component of the renin-angiotensin pathway controlling blood pressure in vertebrates. Using the zebrafish developmental model organism, we study how renin-secreting cells are established in a small region of the early embryo that gives rise to the developing pronephric kidney: the origin of these cells, the factors that induce the differentiation of this cell lineage, and the function of very early renin expression. This study aims to gain in...