Endocrine Abstracts

Pancreatic neuroendocrine tumours (PNETs), although reported with increasing frequency through increased use of abdominal imaging, are rare and uncommon tumours (1 per 100,000 population) representing 1–2% of all pancreatic neoplasms. Preoperative diagnosis is important since a solitary small tumour without evidence of metastatic spread may be suitable for pancreatic preserving surgery such as enucleation or middle segment resection rather than more extensive resection. H...

Dopamine agonists (DA) are very effective and the first-line treatment for hyperprolactinemia. In prolactinoma, DA therapy is the treatment of choice. DA decrease prolactin levels, restore gonadal function, improve visual field defects and reduce tumor size. In some patients drug therapy can lead to a complete remission, including eradication of the tumor, and thereby allow discontinuation of treatment. The majority of the patients, however, have to be treated for many years. ...

The treatment of craniopharyngiomas is associated with long-term morbidity. Although histological benign, intrinsic aggressive biological properties of craniopharyngioma, such as invasion of surrounding tissues, apparently preclude an indolent course. Cardio- and cerebrovascular mortality risk in craniopharyngioma patients is approximately three fold increased. This risk seems to be even greater in estrogen-deficient premenopausal women. In addition, there is a high prevalence...

The mission of the European Reference Network on Rare Endocrine Conditions (Endo-ERN) is to reduce and ultimately abolish inaequalities in care for patients with rare endocrine conditions across Europe. Endo-ERN provides equality between paediatric and adult patients, and is supported by the European Society of Endocrinology and the European Society of Paediatric Endocrinology. In order to achieve Endo-ERN’s mission and accomplish the concrete objectives the first year wa...

My research focuses on the long-term consequences of pituitary diseases, and on the effects of stress hormones on the central nervous system (CNS) in specific. This has elucidated long-term effects of hormone excess on the CNS, as well as on other organs that affect stress-resilience, and consequently, general well-being and quality of life. This profoundly affects our understanding of the biological effects of stress hormone excess on the CNS, and on the care for patients wit...

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patients’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...

Introduction: Children undergoing treatment for cancer are prone to several long-term endocrine complications, which can permanently affect bone tissue.Case report: A 25-year-old man was diagnosed with right maxillary sinus rhabdomyosarcoma at the age of 5. He was submitted to chemotherapy – intrathecal methotrexate+prednisolone and i.v. vincristine+actinomycin+ifosfamide – and submaxillary+cervical radiotherapy, 60Gy. At the age of 12, he was ...

Introduction: The increasing risk of thyroid cancer (TC) in patients who underwent radiotherapy is well documented, especially at early ages. In our center, young patients undergoing cancer treatments are referenced to Endocrine Rehabilitation Clinics (ERC). Their risks are initially identified and monitored regularly. We intended to analyze the characteristics and outcomes of patients who developed post-radiotherapy TC.Methods: Medical records of patien...