Endocrine Abstracts

Recent studies revealed that the elevated tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) serum levels were associated with body fat, especially visceral adiposity, in obese healthy subjects. We investigated the relationship between circulating TNF-alpha and IL-6, parameters of body fatness, and the metabolic syndrome in chronic renal failure maintenance hemodialysis patients.Methods: We explored the relationships between fatness and vis...

Aim/hypothesis: Chronic renal failure maintenance hemodialysis (HD) patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (iPTH) plays a pivotal role in the pathophysiology of uremic bone disease, but in healthy population body weight and particularly body composition are more important determinants of bone mass.Patients and methods: We studied BMD (results were recorded as g/cm2) and T score using D...

Background/Aims: High level of inflammatory cytokines was present within malnourished and chronic renal failure maintenance hemodialysis (MHD) patients, but there were conflicting data about the role of inflammation on development of insulin resistance (IR) in non-obese and overweight MHD patients.Methods: We selected 23 well-nourished and 20 middle- to moderate-malnourished, sex and age-matched, stable MHD patients, 23 male and 20 female, with median di...

Bacground: In type 2 diabetes mellitus (T2DM), the level of polyunsaturated fatty acids (PUFA), is usually decreased, and could be accused for metabolic disturbance, chronic inflammation, and accelerated atherosclerosis. The aim of this study was to determine if there is any relationship between composition of plasma phospholipids PUFAs and parameters of metabolic syndrome.Methods: The study was cross-sectional. Fifteen T2DM patients 63.22±7.20, BMI...

Background and aim: Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients.Patients and methods: We investigated the effects of 6 months-...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...