Endocrine Abstracts

Background/aims: Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues including liver. It has been shown that chronic diseases with liver involvement might cause IGF1 deficiency. The aim of the study was to assess the IGF1 system in adult patients with type 1 Gaucher disease with and without enzyme replacement therapy (...

Introduction: Lesions of the pituitary stalk (PSL) are a challenging diagnostic problem for clinicians. Because of the critical location and role of the pituitary stalk, mass lesions in this area are not often biopsied, and the diagnosis may be based on clinical evaluation and imaging. Due to biopsy risk, about 40% PSL diagnosis are ‘probable’ or ‘unknown’.The main clinical symptoms of PSL are visual field defect, DI and hypopituitarism.<p class="abstex...

Presumption, nausea, bowel distension, abdominal pain and early satiety are very common in patients with Anorexia nervosa (AN). These problems may give rise to significant medical complications and may contribute to increased difficulties with refeeding and weight restoration. The aim of our study was to evaluate the influence of gatrointestinal treatment on weight gain in AN patients. Esophagogastroduodenoscopy with gastric mucose biopsy were performed in 19 AN patients (DSM-...

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...

Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency due to potent non-osmotic stimulation of vasopressin release under stressful conditions. Patients and methods: In a retrospective study 25 patients (13f/12m, age 58.9±18.6 years) with hyponatremia (119.7±10.5 mmol/l) were identified among 260 in-patients treated for hypopituitarism in our department over a decade. Results: Hyponatremia was recorded in 9.6% of our patients. In 84% it was the k...

Introduction: Skeletal complications are among most persistent and invalidating systemic impacts of acromegaly. Assessment of bone health in acromegaly by dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading.Patients and methods: Patients with acromegaly (n=170) were classified as active (n=104), operatively cured (n=34) or medically controlled (n=32). We excluded patients with metabolic bone ...

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...

Introduction: Thyroid dysfunction may cause various psychiatric symptoms and disturbances. In addition, many factors affect the variable responses to hormone replacement. Many patients treated for Hashimoto thyroiditis(HT) report persistent impairments in general well-being despite long-term L-thyroxine (LT4) replacement and restoration of biochemical euthyroidism.Aim: To investigate the prevalence of depression and anxiety in patients with HT on long-te...