Endocrine Abstracts

Introduction: Thyrotoxicosis has been shown to cause deterioration of glucose levels in patients with DM 2 while return to euthyroidism results in better glycaemic control. Studies in normal subjects suggest that increased thyroid hormones may aggravate insulin resistance and decrease pancreatic secretion of insulin but the exact underlying mechanisms have not been completely elucidated. The purpose of this study was to investigate if this also occurs in subclinical hyperthyro...

Background and aims: DM2 has been associated with altered levels of trace elements and a prothrombotic state. We investigated the effect of a 28-day Greek mediterranean diet (rich in fiber, mono- and polyunsaturated fatty acids and complex carbohydrates) on serum concentration of trace ele-ments and blood factors participating in coagulation and fibrinolysis in 58 patients with DM2.Materials and methods: Blood trace elements and blood coagulation fac-tor...

Background & aims: Impaired glucose tolerance and diabetes as well as cardiac dysfunction are known complications in homozygous beta-thalassemic transfused patients due to iron overload. We aimed to study pancreatic alpha and beta-cell function in regularly transfused patients with homozygous beta-thalassemia and to investigate if cardiac dysfunction may correlate with the development of impaired glucose metabolism.Methods: An oral glucose tolerance ...

Background and aims: It is well recognized that insulin resistance and type 2 diabetes (T2DM) are associated with an increased risk for cardiovascular disease especially in women, while the role of sex steroids is still controversial. Women with polycystic ovary syndrome (PCOS) represent a unique biological model for the study of the impact of all these factors on cardiovascular system. We aimed to evaluate the degree of low-grade inflammation and atherosclerosis in premenopau...

Background and aims: Polycystic ovary syndrome (PCOS) and the metabolic syndrome (MS) have many features in common and may share the same pathogenesis. We examined the prevalence of the MS according to the ATP III criteria and the effect of family history for DM 2 on metabolic profile in young women with PCOS.Subjects and methods: We studied 75 women with PCOS aged (23.9±5.4) and 75 healthy age-matched women. We measured BMI, WHR and blood pressure ...