Endocrine Abstracts

Objective: The Fas/Fas ligand (FasL) apoptotic pathway is activated in patients with autoimmune thyroid disease (AITD). It is believed that Fas and FasL expression in intrathyroidal T lymphocytes and thyrocytes is regulated in a manner resulting in thyroid cell apoptosis in Hashimoto’s thyroiditis (HT) or lymphocyte apoptosis in Graves’ disease (GD). The hypothesis that Fas and FasL may be differentially expressed on peripheral lymphocytes in patients with HT and GD ...

Introduction-objective: Fas-mediated thyroid cell apoptosis is differentially regulated in autoimmune thyroid disease (AITD) being up-regulated in Hashimoto’s thyroiditis (HT) and down-regulated in Graves’ disease (GD). The soluble form of Fas (sFas), lacking the transmembrane domain due to alternative splicing may inhibit apoptosis by binding to Fas ligand. In this preliminary study we examined whether sFas is also differentially expressed in patients with AITD....

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, ...

BackgroundRecent knowledge implicates a differential expression of the insulin-like growth factor-1 (IGF-1) mRNA splice variants (i.e., IGF-1Ea, IGF-1Eb and IGF-1Ec) in cancerous tissues, implying possible specific roles of the encoded IGF-1 protein isoforms in cancer biology. In particular, there is growing evidence that IGF-1Ec isoform may plays a distinct biological role in various types of cancer. The aim of the present study was to investigate wheth...

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...

Introduction: Polymorphisms of the receptor for advanced glycation end products (AGEs), RAGE, have been associated with autoimmune disorders and their complications. There are no studies concerning Hashimoto’s thyroiditis (HT); the aim of our study was to investigate the possible role of two RAGE polymorphisms (−429T>C, −374T>A) in combination with indices of oxidative status in women with HT.Design: We examined 300 euth...

Introduction: Despite the fact that CS is widely employed, further investigation on the topic of the physiology vis a vis this type of delivery is required, especially regardingstress related hormonal response during this practice. The aim of this study is to provide data regarding stress related hormonal response during Vaginal Delivery (VD) and elective CS evaluating levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1).<p...

BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...

Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...