Searchable abstracts of presentations at key conferences in endocrinology

ea0015p131 | Diabetes, metabolism and cardiovascular | SFEBES2008

Factors effecting CHD risk reduction in patients with type 2 diabetes and microalbuminuria

Rajaratnam Simon , Phillipov George , Phillips Patrick

The UKPDS study has shown that, intensive lowering of blood sugar and blood pressure decreases the risk of micro vascular complications in individuals with type 2 diabetes. The Steno-2 study has shown that target driven, long-term intensive treatment in patients with type 2 diabetes and microalbuminuria reduces the risk of cardiovascular and micro vascular events by about 50%.We investigated the effect on the 10 years absolute CHD risk of our type 2 diab...

ea0006ds3 | Hypertension and diabetes | SFE2003

Epidemiology of hypertension and diabetes

Phillips D

Hypertension and diabetes are prevalent conditions. Population studies suggest that blood pressure in excess of 140/90 mmHg is found in nearly 30% of adults while type 2 diabetes occurs in 3-4%. However, both conditions are strongly age-dependent, and exhibit large geographical variations. Non-european populations typically have much higher prevalence rates. Worldwide, there has been a dramatic increase in the occurrence of type 2 diabetes. It has long been known that these co...

ea0081ep683 | Pituitary and Neuroendocrinology | ECE2022

Pituitary Coma? Discordant pituitary biochemistry after consumption of a commercially available ‘Sleep Activator’.

Phillips Benjamin , Kumar Mohit

We present a case of discordant pituitary biochemistry which resolved after discontinuing a commercially available combination vitamin supplement. A 35 year-old man presented following an episode of headache and dizziness, preceding collapse and possible seizure activity. Investigations revealed deranged pituitary function: TSH 0.02 mU/l (0.35-5.50), fT4 3.6 pmol/l (10.0-20.0), 9 am cortisol 18 nmol/l (200-500), testosterone >52 nmol/l (8.4-28.7), FSH <0.3 U/l (1.0-18....

ea0038p52 | Clinical practice/governance and case reports | SFEBES2015

Impact of a multidisciplinary diabetic foot clinic on patient outcomes

Phillips Lowri , Osborne Louise

Introduction: Foot disease in diabetes is associated with significant morbidity and mortality. Diabetic foot disease requires complex care with input from a range of healthcare professionals. Scottish Intercollegiate Guidelines Network guideline 116 recommends that all patients with diabetes and foot ulceration are seen at a multidisciplinary foot clinic. Our aim was to assess the impact on patient outcomes of introducing a multidisciplinary foot clinic within NHS Fife.<p ...

ea0010p4 | Clinical case reports/Governance | SFE2005

Persistent partial hypopituitarism following an episode of cerebral oedema caused by diabetic ketoacidosis

Phillips S , Al-Mrayat M

There have been several case reports over the years of hypopituitarism occurring after cerebral oedema caused by diabetic ketoacidosis (DKA). The case reports have ranged from a single hormone defect to a more extensive loss of hormone production. What is not reported in the literature so far is what happens to these patients and their hormone deficiencies in the longer term.This is a case report of a young man who presented with DKA aged twelve who rapi...

ea0044p71 | Clinical biochemistry | SFEBES2016

Evaluation of diagnostic cut-offs for aldosterone-renin ratio using iSYS assays for aldosterone and direct renin

Fairclough Charlotte , Milan Anna , Phillips Suzannah

Introduction: ‘Primary Aldosteronism Detection, Diagnosis and Treatment Guidelines’ from the Endocrine Society (2008) recommend the use of the aldosterone- renin ratio (ARR) to detect primary aldosteronism (PA) in patient groups with high prevalence of PA. The guidelines suggest cut-offs specific to assay type and measurement units. The department of Clinical Chemistry and Metabolic Medicine at RLBUHT recently moved to a direct renin method (iSYS, Immunodiagnostics) ...

ea0025s4.3 | Endocrine regulation of ageing | SFEBES2011

Cortisol, DHEAS and immunesenescence

Lord Janet , Phillips Anna , Arlt Wiebke

Normal ageing is accompanied by increased organismal frailty, reflecting organ specific functional decline, with an associated increase in the likelihood of disease. The immune system undergoes significant decline with age, termed immunesenescence, which results in increased susceptibility to infection and reduced vaccination responses. Significant changes in the hormonal milieu also occur with age and it is clear that age-related changes in adrenal hormone secretion can impos...

ea0007p281 | Clinical case reports | BES2004

Recognition of Smith Lemli Opitz syndrome by characteristic steroids

Honour J , Phillips I , Conway E

Congenital adrenal hyperplasia(CAH) and other disorders of adrenal steroid synthesis compromise synthesis of cortisol and aldosterone. Deficiency of 7-dehydrocholesterol-7-ene-reductase (DHCR7) in the Smith Lemli Opitz syndrome (SLOS) also affects cholesterol synthesis. New-born infants have dysmorphic facial features, microcephaly, second and third toe syndactyly and genital malformations. Later there is mental retardation and problems with cardiac and intestinal function thr...

ea0044ep27 | (1) | SFEBES2016

Maternal hypercalcaemia due to CYP24A1 loss of function mutations

Upton Thomas , Florkowski Chris , Phillips Ian , Hunt Penny

Background: Significant changes in calcium metabolism occur during normal pregnancy to meet the needs of the growing fetus. These include a rise in 1,25-dihydroxyvitamin D (1,25-(OH)D2 and consequent suppression of parathyroid hormone (PTH). In spite of this, maternal hypercalcaemia is very uncommon and should prompt further investigation.Clinical case: A 24-year-old primigravida woman was referred for assessment of maternal hypercalcaemia. Sh...

ea0034p49 | Clinical biochemistry | SFEBES2014

Do we need method specific cortisol cut off limits for dynamic function tests?

Braha Kate , Phillips Suzannah , Dutton John , Milan Anna

Measurement of cortisol is used in the differential diagnosis of Addisons’ disease (deficiency), Cushing’s disease (excess), hypopituitarism, adrenal hyperplasia and carcinoma. Cortisol is routinely measured by immunoassay, which has wide inter-assay variability with manufacturer dependent bias. Despite this, universal cut-offs are used as criteria for interpretation of dynamic function tests of the pituitary adrenal axis.Using a fully validate...