Endocrine Abstracts

GIP-dependent Cushing’s syndrome (CS) is caused by ectopic expression in adrenal cortex of gastric inhibitory peptide (GIP) receptors coupled to steroidogenesis, which leads to postprandial increases of cortisol (food-dependent CS). In a few cases a transient effect of short-acting octreotide on cortisol levels has been shown, but bilateral adrenalectomy is still thought to be a definitive treatment.We report on a case of a 45-year old woman with bi...

Introduction: Besides of the neuroendocrine actions including the stimulatory effects on growth hormone, prolactin and adrenocorticotropin release, acylated ghrelin (AG) plays a role in the regulation of metabolic processes, resulting in the decrease of insulin secretion and increase of hepatic glucose release. Despite of many earlier studies, the mechanisms involved in AG secretion have not been established. The aim of study was to assess the influence of leptin on AG.<p ...

Obesity is considered as a state of chronic, systemic low-grade inflammation. Likely causes include infectious factors, leptin, cigarette smoking, low serum HDL-cholesterol and high serum triglycerides. No definitive confirmation on the causative factor is available so far.The aim of the study was to evaluate serum levels of C-reactive protein (hs-CRP, sensitivity 0,085 ng/L), IL-6, IL-10, TNF-α and its soluble type 2 receptor (sTNF-αR-2) in vi...