Searchable abstracts of presentations at key conferences in endocrinology

ea0022p358 | Diabetes | ECE2010

Antioxidative effect of green tee and red wine polyphenol extracts on RINm5F cells after oxidative stress induction

Auberval Nathalie , Ros Stephanie , Schini-Kerth Valerie , Pinget Michel , Sigrist Severine

Diabetes is associated with an oxidative stress (OS). Free radicals are responsible of β-cell destruction in type 1 diabetes and their dysfunction in type 2. The purpose of this work is to evaluate preventive effect of antioxidative natural compounds on several models of OS induced on β-cells.The models of oxidative stress were performed with 40 μmol/l H2O2 for 30 min, with a mixture of 0.25 mmol/l hypoxanthine and 10...

ea0011p150 | Clinical case reports | ECE2006

A case report of malignant insulinoma

Jeandidier N , Boullu S , Ciarloni L , Drui S , Louis B , Pinget M , Kurtz JE , Chabrier G

Insulinoma is a rare neuroendocrine tumor (4 cases/1000000/year), less than 10% are malignant. We report a case of rapidly fatal malignant insulinoma, death occurring less than 3 months after the apparition of hypoglycaemic symptoms.A 79 years old female type 2 diabetic patient, treated with glicazide120 mg b.i.d and metformine et 850 t.i.d, was hospitalized for recurrent hypoglycaemia Insulinoma was diagnosed as severe hypoglycaemic episodes occurred mo...

ea0022p354 | Diabetes | ECE2010

Renal complications of aldosteronism and diabetes: role of oxidative stress and protective effects of polyphenol extract

Elowe-Gruau Eglantine , Dal-Ros Stephanie , Auberval Nathalie , Seyfritz Elodie , Bietiger William , Pinget Michel , Jeandidier Nathalie , Sigrist Severine

Hyperaldosteronism and diabetes are two providers of kidney disease, showing molecular and cellular mechanisms in common, such as oxidative stress, causing renal tubular damages. The objective of this study is to evaluate in vitro the protective effect of a natural antioxidant (red wine polyphenols and green tea extract) in the onset of renal dysfunction. Hyperglycemia and hyperaldosteronism are induced respectively by increasing doses of glucose and aldosterone in prim...